About: INITIAL HIGH VIRAL LOAD IS ASSOCIATED WITH PROLONGED SHEDDING OF HUMAN RHINOVIRUS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS

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About: INITIAL HIGH VIRAL LOAD IS ASSOCIATED WITH PROLONGED SHEDDING OF HUMAN RHINOVIRUS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	INITIAL HIGH VIRAL LOAD IS ASSOCIATED WITH PROLONGED SHEDDING OF HUMAN RHINOVIRUS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS
Creator	Campbelld, P Englundd, A Jeromed, R Kuypersd, Xjane Leisenringd, M Xalpana, X Xangela, X Xchikara Ogimid, X Xied, Xhu Xjanet, X Xkeith, X Xmichael Boeckhd, X Xwendy, X
Source	Elsevier; Medline; PMC
abstract	INTRODUCTION: Recent data suggest human rhinovirus (HRV) is associated with lower respiratory tract infection and mortality in hematopoietic cell transplant (HCT) recipients. Examining risk factors for prolonged viral shedding may provide critical insight for the development of novel therapeutics and help inform infection prevention practices. Our objective was to identify risk factors for prolonged shedding of HRV post-HCT. MATERIALS AND METHODS: We prospectively collected weekly nasal samples from allogeneic HCT recipients from day 0 to day 100 post-transplant, and performed realtime RT-PCR (12/2005 to 2/2010). Subjects with symptomatic HRV infection and a negative test within 2 weeks of the last positive were included. Duration of shedding was defined as time between the first positive and first negative samples. Cycle threshold (Ct) values were used as a proxy for viral load. HRV species were identified by sequencing the 5’ non-coding region. Logistic regression analyses were performed to evaluate factors associated with prolonged shedding (≥21 days). RESULTS: We identified 38 HCT recipients with HRV infection fulfilling study criteria (32 adults, 6 children). Median duration of shedding was 9.5 days (2-89 days); 18 patients had prolonged shedding. Among 26 samples sequenced, 69% were species A, and species B and C accounted for 15% each; the median shedding duration of HRV did not differ between species (P = 0.17). Bivariable logistic regression analyses suggest that initial high viral load (low Ct value) is associated with prolonged shedding. CONCLUSIONS: HCT recipients with initial high viral loads are at risk for prolonged HRV viral shedding.
has issue date	2018-10-01(xsd:dateTime)
bibo:doi	10.1016/j.bbmt.2018.07.006
bibo:pmid	30009982
has license	hybrid-oa
sha1sum (hex)	03be1b13bb27c345596bc823c25963ebeb990640
schema:url	https://doi.org/10.1016/j.bbmt.2018.07.006
resource representing a document's title	INITIAL HIGH VIRAL LOAD IS ASSOCIATED WITH PROLONGED SHEDDING OF HUMAN RHINOVIRUS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS
has PubMed Central identifier	PMC6239940
has PubMed identifier	30009982
schema:publication	Biology of Blood and Marrow Transplantation
resource representing a document's body	covid:03be1b13bb27c345596bc823c25963ebeb990640#body_text
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