About: The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract
Creator	Nicholls, John Hospital, Mary Kong, Hong Lam, Pok
Source	PMC
abstract	Influenza is a viral infection of the respiratory tract. Infection is normally confined to the upper respiratory tract but certain viral strains have evolved the ability to infect the lower respiratory tract, including the alveoli, leading to inflammation and a disease pattern of diffuse alveolar damage. Factors leading to this sequence of events are novel influenza strains, or strains that have viral proteins, in particular the NS1 protein that allow it to escape the innate immune system. There are three main barriers that prevent infection of pneumocytes - mucin, host defence lectins and cells such as macrophages. Viruses have developed strategies such as neuraminidase and glycosylation patterns that allow this evasion. Though there has been much investment in antiviral drugs, it is proposed that more attention should be directed towards developing or utilizing compounds that enhance the ability of the innate immune system to combat viral infection.
has issue date	2013-03-29(xsd:dateTime)
bibo:doi	10.3947/ic.2013.45.1.11
bibo:pmid	24265946
has license	cc-by-nc
sha1sum (hex)	035dc4021101af0a19152cb5ea7b40b0c57ed76d
schema:url	https://doi.org/10.3947/ic.2013.45.1.11
resource representing a document's title	The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract
has PubMed Central identifier	PMC3780943
has PubMed identifier	24265946
schema:publication	Infect Chemother
resource representing a document's body	covid:035dc4021101af0a19152cb5ea7b40b0c57ed76d#body_text
is schema:about of	named entity 'BATTLE' named entity 'respiratory tract' named entity 'innate immune system' named entity 'glycosylation' named entity 'infection' named entity 'Respiratory' named entity 'ABILITY TO' named entity 'INCLUDING' named entity 'PREVENT' named entity 'ESCAPE' named entity 'HOST' named entity 'GLYCOSYLATION' named entity 'TO INFECT' named entity 'LECTINS' named entity 'PROPOSED' named entity 'PROTEIN ' named entity 'VIRAL PROTEINS' named entity 'HUMAN' named entity 'INNATE IMMUNE RESPONSE' named entity 'INFLUENZA' named entity 'VIRAL INFECTION' named entity 'CELLS' named entity 'ENHANCE' named entity 'IS A' named entity 'LEADING' named entity 'MUCH' named entity 'VIRUSES' named entity 'ALVEOLI' named entity 'MUCIN' named entity 'EVOLVED' named entity 'PARTICULAR' named entity 'INFLAMMATION' named entity 'PATTERNS' named entity 'DIRECTED' named entity 'ALLOW' named entity 'RESPIRATORY TRACT' named entity 'INNATE IMMUNE SYSTEM' named entity 'NOVEL' named entity 'STRATEGIES' named entity 'STRAINS' named entity 'SEQUENCE' named entity 'ANTIVIRAL DRUGS' named entity 'HAVE' named entity 'INVESTMENT' named entity 'INFLUENZA' named entity 'NS1 PROTEIN' named entity 'EVENTS' named entity 'RESPIRATORY TRACT' named entity 'DISEASE' named entity 'PNEUMOCYTES' named entity 'UPPER RESPIRATORY TRACT' named entity 'COMBAT' named entity 'NEURAMINIDASE' named entity 'LOWER RESPIRATORY TRACT' named entity 'CERTAIN' named entity 'DIFFUSE ALVEOLAR DAMAGE' named entity 'MAIN' named entity 'VIRAL' named entity 'PATTERN' named entity 'DEVELOPING' named entity 'ATTENTION' named entity 'MACROPHAGES' named entity 'INFECTION' named entity 'BUT' named entity 'cells' named entity 'strains' named entity 'mucin' named entity 'leading' named entity 'strains' named entity 'proteins' named entity 'protein' named entity 'antiviral drugs' named entity 'protein' named entity 'viral infection' named entity 'innate immune' named entity 'glycosylation' named entity 'Influenza' named entity 'mucin'

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