About: EMERGING SPECTRUM OF CARDIOPULMONARY PATHOLOGY OF THE CORONAVIRUS DISEASE 2019 (COVID-19): REPORT OF THREE AUTOPSIES FROM HOUSTON, TEXAS AND REVIEW OF AUTOPSY FINDINGS FROM OTHER UNITED STATES CITIES

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About: EMERGING SPECTRUM OF CARDIOPULMONARY PATHOLOGY OF THE CORONAVIRUS DISEASE 2019 (COVID-19): REPORT OF THREE AUTOPSIES FROM HOUSTON, TEXAS AND REVIEW OF AUTOPSY FINDINGS FROM OTHER UNITED STATES CITIES Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	EMERGING SPECTRUM OF CARDIOPULMONARY PATHOLOGY OF THE CORONAVIRUS DISEASE 2019 (COVID-19): REPORT OF THREE AUTOPSIES FROM HOUSTON, TEXAS AND REVIEW OF AUTOPSY FINDINGS FROM OTHER UNITED STATES CITIES
Creator	Madjid, Mohammad Aisenberg, Gabriel Akkanti, Bindu Kar, Biswajit Lelenwa, Laura Ottaviani, Giulia Trujillo, Daniel Wolf, Dwayne Zhao, Bihong Buja, L Buja, Maximilian Do, Michelle Do, Noah Tarek, M
Source	Elsevier; Medline; PMC; WHO
abstract	Abstract This paper collates the pathological findings from initial published autopsy reports on 23 patients with Coronavirus Disease 2019 (COVID-19) from 5 centers in the United States of America, including 3 cases from Houston, Texas. Findings confirm that COVID-19 is a systemic disease with major involvement of the lungs and heart. Acute COVID-19 pneumonia has features of a distinctive acute interstitial pneumonia with: a diffuse alveolar damage (DAD) component, coupled with microvascular involvement with intra- and extra-vascular fibrin deposition and intravascular trapping of neutrophils, and, frequently, with formation of microthombi in arterioles. Major pulmonary thromboemboli with pulmonary infarcts and/or hemorrhage occurred in 5 of the 23 patients. Two of the Houston cases had interstitial pneumonia with DAD pattern. One of the Houston cases had multiple bilateral segmental pulmonary thromboemboli with infarcts and hemorrhages coupled with, in non-hemorrhagic areas, a distinctive interstitial lymphocytic pneumonitis with intra-alveolar fibrin deposits and no hyaline membranes, possibly representing a transition form to acute fibrinous and organizing pneumonia (AFOP). Multifocal acute injury of cardiac myocytes was frequently observed. Lymphocytic myocarditis was reported in 1 case. In addition to major pulmonary pathology, the three Houston cases had evidence of lymphocytic pericarditis, multifocal acute injury of cardiomyocytes without inflammatory cellular infiltrates, depletion of splenic white pulp, focal hepatocellular degeneration and rare glomerular capillary thrombosis. Each had evidence of chronic cardiac disease: hypertensive left ventricular hypertrophy (420 gram heart), dilated cardiomyopathy (1070 gram heart), and hypertrophic cardiomyopathy (670 gram heart). All three subjects were obese (BMIs of 33.8, 51.65 and 35.2 Kg/m2). Overall, the autopsy findings support the concept that the pathogenesis of severe COVID-19 disease involves direct viral-induced injury of multiple organs, including heart and lungs, coupled with the consequences of a procoagulant state with coagulopathy.
has issue date	2020-05-07(xsd:dateTime)
bibo:doi	10.1016/j.carpath.2020.107233
bibo:pmid	32434133
has license	els-covid
sha1sum (hex)	0355b0c49d3caf6d131c5174d87a8456d54b9a55
schema:url	https://doi.org/10.1016/j.carpath.2020.107233
resource representing a document's title	EMERGING SPECTRUM OF CARDIOPULMONARY PATHOLOGY OF THE CORONAVIRUS DISEASE 2019 (COVID-19): REPORT OF THREE AUTOPSIES FROM HOUSTON, TEXAS AND REVIEW OF AUTOPSY FINDINGS FROM OTHER UNITED STATES CITIES
has PubMed Central identifier	PMC7204762
has PubMed identifier	32434133
schema:publication	Cardiovasc Pathol
resource representing a document's body	covid:0355b0c49d3caf6d131c5174d87a8456d54b9a55#body_text
is schema:about of	named entity 'thrombotic microangiopathy' named entity 'DAD' named entity 'coagulopathy' named entity 'autopsy studies' named entity 'CD68+ macrophages' named entity 'pathology' named entity 'D-dimer' named entity 'TEXAS' named entity 'Endothelial cell' named entity 'acute febrile respiratory illness' named entity 'postmortem' named entity 'cardiomyocyte' named entity 'China' named entity 'membrane oxygenator' named entity 'cytopathic effect' named entity 'obesity' named entity 'chronic inflammation' named entity 'parenchyma' named entity 'obesity' named entity 'exudate' named entity 'autopsies' named entity 'fibrin' named entity 'cardiomyocyte' named entity 'dilated cardiomyopathy' named entity 'medicolegal' named entity 'alveolar spaces' named entity 'fever' named entity 'heart strain' named entity 'myocardium' named entity 'COVID' named entity 'ARDS' named entity 'pulmonary disease' named entity 'thrombosis' named entity 'liver' named entity 'pathogenesis' named entity 'renal injury' named entity 'inflammatory reaction' named entity 'Occupational Safety and Health Administration' named entity 'COVID' named entity 'red pulp' named entity 'Prognostic' named entity 'viral particles' named entity 'troponin' named entity 'OSHA' named entity 'autopsy' named entity 'COVID' named entity 'DAD' named entity 'chills' named entity 'pathology' named entity 'inflammation' named entity 'splenectomy' named entity 'CD4+' named entity 'autopsies' named entity 'hyaline' named entity 'fibrin' named entity 'COVID' named entity 'autopsy' named entity 'CDC' named entity 'thrombotic events' named entity 'pneumonia' named entity 'COVID' named entity 'anticoagulants' named entity 'fever' named entity 'COVID' named entity 'Influenza infection' named entity 'cryptogenic organizing pneumonia' named entity 'COVID' named entity 'thrombi'

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