About: Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

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About: Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors
Creator	Park, Ji-Young Kim, Kyung Lee, Woo Lim, Su Park, Ki Ryu, Young Won Ryu, Hyung Yuk, Joo
source	Medline; PMC
abstract	The current study was designed to assess the inhibitory activity of Broussonetia papyrifera-derived polyphenols against 3-chymotrypsin-like and papain-like coronavirus cysteine proteases. The isolated compounds were broussochalcone B (1), broussochalcone A (2), 4-hydroxyisolonchocarpin (3), papyriflavonol A (4), 3′-(3-methylbut-2-enyl)-3′,4,7-trihydroxyflavane (5), kazinol A (6), kazinol B (7), broussoflavan A (8), kazinol F (9), and kazinol J (10). All polyphenols were more potent against papain-like protease (PL(pro)) than against 3-chymotripsin-like protease (3CL(pro)); therefore, we investigated their structural features that were responsible for this selectivity. Compound 4 was the most potent inhibitor of PL(pro) with an IC(50) value of 3.7 μM. The active compounds displayed kinetic behaviors, and the binding constants of their interaction with PL(pro) were determined from surface plasmon resonance analysis. Our results suggest B. papyrifera constituents as promising candidates for development into potential anti-coronaviral agents.
has issue date	2017-01-22(xsd:dateTime)
bibo:doi	10.1080/14756366.2016.1265519
bibo:pmid	28112000
has license	cc-by
sha1sum (hex)	02d808df510466b74102dd922486bf922a5ed947
schema:url	https://doi.org/10.1080/14756366.2016.1265519
resource representing a document's title	Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors
has PubMed Central identifier	PMC6010046
has PubMed identifier	28112000
schema:publication	J Enzyme Inhib Med Chem
resource representing a document's body	covid:02d808df510466b74102dd922486bf922a5ed947#body_text
is schema:about of	named entity 'All' named entity 'protease' named entity 'compounds' named entity 'CONSTITUENTS' named entity 'VALUE' named entity 'FEATURES' named entity '2C4' named entity 'INHIBITORY ACTIVITY' named entity 'KAZINOL B' named entity 'CONSTANTS' named entity 'STUDY' named entity 'THEIR' named entity '283' named entity 'PRO' named entity 'KAZINOL A' named entity 'CORONAVIRUS' named entity '3.7' named entity 'ACTIVE' named entity 'POLYPHENOLS' named entity 'INHIBITOR' named entity 'POLYPHENOLS' named entity 'EVALUATION' named entity 'INTERACTION' named entity 'DETERMINED' named entity 'CHYMOTRYPSIN' named entity 'KINETIC' named entity 'BROUSSOCHALCONE A' named entity 'OUR' named entity 'PAPAIN' named entity 'ISOLATED' named entity 'SELECTIVITY' named entity 'INVESTIGATED' named entity 'BROUSSONETIA PAPYRIFERA' named entity 'RESPONSIBLE' named entity 'CORONAVIRUS' named entity '288' named entity 'CURRENT' named entity 'BEHAVIORS' named entity 'CYSTEINE PROTEASES' named entity 'DERIVED' named entity '282' named entity 'POTENTIAL' named entity 'RESULTS' named entity 'SURFACE PLASMON RESONANCE' named entity 'ANTI-CORONAVIRAL AGENTS' named entity 'ASSESS' named entity 'PAPYRIFLAVONOL A' named entity 'BINDING' named entity '287' named entity 'SUGGEST' named entity 'PROTEASE' named entity 'STRUCTURAL' named entity 'DISPLAYED' named entity 'ANALYSIS' named entity 'COMPOUND' named entity 'BROUSSONETIA PAPYRIFERA' named entity 'PROTEASE INHIBITORS' named entity 'DEVELOPMENT' named entity 'LIKE' covid:arg/02d808df510466b74102dd922486bf922a5ed947 named entity 'kinetic' named entity 'surface plasmon' named entity 'constituents' named entity 'assess' named entity 'protease' named entity 'potential' named entity 'inhibitory activity' named entity 'polyphenols' named entity 'surface plasmon resonance' named entity 'protease inhibitors' named entity 'MERS-CoV' named entity 'proteases' named entity 'inhibitory activity' named entity 'NHS'

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