About: Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases
Creator	Harthill, Michalann
Source	Medline; PMC
abstract	Recently emerged viral infectious diseases (VIDs) include HIV/AIDS, influenzas H5N1 and 2009 H1N1, SARS, and Ebola hemorrhagic fevers. Earlier research determined metabolic oxidative stress in hosts deficient in antioxidant selenium (Se) (<1 μMol Se/L of blood) induces both impaired human host immunocompetence and rapidly mutated benign variants of RNA viruses to virulence. These viral mutations are consistent, rather than stochastic, and long-lived. When Se-deficient virus-infected hosts were supplemented with dietary Se, viral mutation rates diminished and immunocompetence improved. Herein is described the role of micronutrient Se deficiency on the evolution of some contemporary RNA viruses and their subsequent VIDs. Distinguishing cellular and biomolecular evidence for several VIDs suggests that environmental conditions conducive to chronic dietary Se deprivation could be monitored for bioindicators of incipient viral virulence and subsequent pathogenesis.
has issue date	2011-02-12(xsd:dateTime)
bibo:doi	10.1007/s12011-011-8977-1
bibo:pmid	21318622
has license	no-cc
sha1sum (hex)	02d18b629aa57f2676db338d4ffd1e25caef9c85
schema:url	https://doi.org/10.1007/s12011-011-8977-1
resource representing a document's title	Review: Micronutrient Selenium Deficiency Influences Evolution of Some Viral Infectious Diseases
has PubMed Central identifier	PMC7090490
has PubMed identifier	21318622
schema:publication	Biol Trace Elem Res
resource representing a document's body	covid:02d18b629aa57f2676db338d4ffd1e25caef9c85#body_text
is schema:about of	named entity 'SELENIUM DEFICIENCY' named entity 'METABOLIC' named entity 'CHRONIC' named entity 'MUTATED' named entity 'RESEARCH' named entity 'MONITORED' named entity 'THESE' named entity 'CONSISTENT' named entity 'BENIGN' named entity 'MUTATIONS' named entity 'RAPIDLY' named entity 'IMPROVED' named entity 'STOCHASTIC' named entity 'BIOINDICATORS' named entity 'DEFICIENT' named entity 'RNA VIRUSES' named entity 'DISTINGUISHING' named entity 'CELLULAR' named entity 'VIRAL' named entity 'MICRONUTRIENT' named entity 'MICRONUTRIENT' named entity 'VIRAL INFECTIOUS DISEASES' covid:arg/02d18b629aa57f2676db338d4ffd1e25caef9c85 named entity 'EVOLUTION' named entity 'COULD BE' named entity 'RATHER' named entity 'DIMINISHED' named entity 'DETERMINED' named entity 'EARLIER' named entity 'SARS' named entity 'INCIPIENT' named entity 'INFECTED' named entity 'HEMORRHAGIC FEVERS' named entity 'DEPRIVATION' named entity 'ANTIOXIDANT' named entity 'HOSTS' named entity 'PATHOGENESIS' named entity 'ENVIRONMENTAL' named entity 'EVIDENCE FOR' named entity 'H5N1' named entity 'EVOLUTION' named entity 'HIV' named entity 'ROLE' named entity 'REVIEW' named entity 'DEFICIENCY' named entity 'HUMAN' named entity 'VIRUS' named entity 'VARIANTS' named entity 'LONG' named entity 'H1N1' named entity 'SELENIUM' named entity 'MUTATION RATES' named entity 'RECENTLY' named entity 'IMPAIRED' named entity 'OXIDATIVE STRESS' named entity 'THEIR' named entity 'SUBSEQUENT' named entity 'IMMUNOCOMPETENCE' named entity 'CONDITIONS' named entity 'HOST' named entity 'DESCRIBED' named entity 'DIETARY' named entity 'EBOLA' named entity 'VIRULENCE' named entity 'INFLUENZAS' named entity 'INCLUDE' named entity 'VIRAL INFECTIOUS DISEASES' named entity 'BLOOD' named entity 'hemorrhagic fevers' named entity 'immunocompetence' named entity 'virus' named entity 'bioindicators' named entity 'antioxidant' named entity 'infectious diseases' named entity 'metabolic' named entity 'environmental conditions' named entity 'IgG' named entity 'VIDs' named entity 'antioxidant' named entity 'epithelium' named entity 'host immune responses'

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