About: Sequence analysis of the 3′ end of the feline coronavirus FIPV 79-1146 genome: Comparison with the genome of porcine coronavirus TGEV reveals large insertions

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About: Sequence analysis of the 3′ end of the feline coronavirus FIPV 79-1146 genome: Comparison with the genome of porcine coronavirus TGEV reveals large insertions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sequence analysis of the 3′ end of the feline coronavirus FIPV 79-1146 genome: Comparison with the genome of porcine coronavirus TGEV reveals large insertions
Creator	Andeweg, Arno Spaan, Willy De Groot, Raoul Horzinek, Marian
Source	Elsevier; Medline; PMC
abstract	Abstract The genetic information, carried on mRNA 6 of feline infectious peritonitis virus (FIPV) strain 79–1146, was determined by sequence analysis of cDNA clones derived from the 3′ end of the FIPV genome. Two ORFs were found, encoding polypeptides of 11 K (ORF-1) and 22K (ORF-2). The FIPV sequence was compared to the 3′ end sequence of transmissible gastroenteritis virus (TGEV). ORF-1 has a homologous counterpart (ORF-X3) in the TGEV genome; both ORFs are located at the same position relative to the nucleocapsid gene. However, as a result of an in-frame insertion or deletion, ORF-1 is 69 nucleotides larger than ORF-X3. A similar event has occurred immediately downstream of ORF1: a 624-nucleotide segment, containing the complete ORF-2, is absent in the TGEV sequence. Most sequence similarity (98.5%) was found in the 3′ noncoding sequences. ORF-X3 and ORF-1 are preceded by the sequence AAC-TAAAC, which is assumed to be the transcription-initiation signal in FIPV and TGEV (P. A. Kapke and D. A. Brian (1986) Virology 151, 41–49). By S1 nuclease analysis, the 5′ end of FIPV RNA 6 was mapped immediately upstream of this sequence. A 700-nucleotide TGEV-specific RNA was found by cross-hybridization with an FIPV 3′ end probe, suggesting that TGEV ORF-X3 is also carried on a separate mRNA. The differences at the 3′ ends of the FIPV and TGEV genomes maybe the result of RNA recombination events.
has issue date	1988-12-31(xsd:dateTime)
bibo:doi	10.1016/0042-6822(88)90097-9
bibo:pmid	3201747
has license	els-covid
sha1sum (hex)	02569bcf9a7e53d2d262ef58dbfb2f9d38e7c7b2
schema:url	https://doi.org/10.1016/0042-6822%2888%2990097-9
resource representing a document's title	Sequence analysis of the 3′ end of the feline coronavirus FIPV 79-1146 genome: Comparison with the genome of porcine coronavirus TGEV reveals large insertions
has PubMed Central identifier	PMC7130511
has PubMed identifier	3201747
schema:publication	Virology
resource representing a document's body	covid:02569bcf9a7e53d2d262ef58dbfb2f9d38e7c7b2#body_text
is schema:about of	named entity 'Coronavirus' named entity 'End' named entity '1146' named entity 'COMPARISON' named entity 'ORF1' named entity 'UPSTREAM' named entity 'NUCLEOTIDES' named entity 'MAPPED' named entity 'ABSENT' named entity 'VIROLOGY' named entity 'LARGER' named entity 'RNA RECOMBINATION' named entity 'SEGMENT' named entity 'INSERTION OR DELETION' named entity 'CONTAINING' named entity 'IMMEDIATELY' named entity 'GENE' named entity 'POLYPEPTIDES' named entity 'CDNA' named entity 'RNA' named entity 'PRECEDED' named entity 'TRANSCRIPTION-INITIATION' named entity 'CLONES' named entity 'EVENTS' named entity 'COMPLETE' named entity 'SEQUENCE SIMILARITY' named entity 'MAY BE' covid:arg/02569bcf9a7e53d2d262ef58dbfb2f9d38e7c7b2 named entity 'FIPV' named entity 'CORONAVIRUS' named entity 'REVEALS' named entity 'HYBRIDIZATION' named entity 'IN-FRAME INSERTION' named entity 'ORFS' named entity 'AAC' named entity 'GENETIC INFORMATION' named entity 'GENOME' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'NUCLEASE' named entity '1146' named entity 'OCCURRED' named entity 'STRAIN' named entity '28P' named entity 'DERIVED' named entity 'END' named entity 'COMPARED' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'INSERTIONS' named entity 'TGEV' named entity 'POSITION' named entity 'FELINE CORONAVIRUS' named entity 'GENOME' named entity 'SEQUENCE ANALYSIS' named entity 'END' named entity 'LARGE' named entity 'EVENT' named entity 'SEQUENCE ANALYSIS' named entity 'PROBE' named entity 'AS A RESULT OF' named entity '624' named entity 'NUCLEOTIDE' named entity 'MRNA' named entity '700' named entity 'GENOMES' named entity 'RELATIVE TO' named entity 'SEPARATE' named entity 'ENCODING' named entity 'SIMILAR' named entity 'CROSS' named entity 'PORCINE' named entity 'ORF' named entity 'ANALYSIS' named entity 'ASSUMED' named entity 'DETERMINED BY' named entity 'CARRIED' named entity 'SIGNAL' named entity 'FOUND' named entity 'NUCLEOCAPSID'

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