About: Low Serum Mannose-Binding Lectin Level Increases the Risk of Death due to Pneumococcal Infection

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About: Low Serum Mannose-Binding Lectin Level Increases the Risk of Death due to Pneumococcal Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Low Serum Mannose-Binding Lectin Level Increases the Risk of Death due to Pneumococcal Infection
Creator	Hinds, Charles Brett, Stephen Gordon, Anthony Kronborg, Gitte Eisen, Damon Mcbryde, Emma Peters, Mark Dean, Melinda Lau, Yu Boermeester, Marja Fidler, Katy Ip, W Kun, F Mila, Joan Oliver Van Till, J Payeras, Antonis Rgen, Jü Saevarsdottir, Saedis Valdimarsson, Helgi
Source	PMC
abstract	Background. Previous studies have shown associations between low mannose-binding lectin (MBL) level or variant MBL2 genotype and sepsis susceptibility. However, MBL deficiency has not been rigorously defined, and associations with sepsis outcomes have not been subjected to multivariable analysis. Methods. We reanalyzed MBL results in a large cohort with use of individual data from 4 studies involving a total of 1642 healthy control subjects and systematically defined a reliable deficiency cutoff. Subsequently, data were reassessed to extend previous MBL and sepsis associations, with adjustment for known outcome predictors. We reanalyzed individual data from 675 patients from 5 adult studies and 1 pediatric study of MBL and severe bacterial infection. Results. XA/O and O/O MBL2 genotypes had the lowest median MBL concentrations. Receiver operating characteristic analysis revealed that an MBL cutoff value of 0.5 ≪g/mL was a reliable predictor of low-producing MBL2 genotypes (sensitivity, 82%; specificity, 82%; negative predictive value, 98%). MBL deficiency was associated with increased likelihood of death among patients with severe bacterial infection (odds ratio, 2.11; 95% confidence interval, 1.30–3.43). In intensive care unit–based studies, there was a trend toward increased risk of death among MBL-deficient patients (odds ratio, 1.58; 95% confidence interval, 0.90–2.77) after adjustment for Acute Physiology and Chronic Health Enquiry II score. The risk of death was increased among MBL-deficient patients with Streptococcus pneumoniae infection (odds ratio, 5.62; 95% confidence interval, 1.27–24.92) after adjustment for bacteremia, comorbidities, and age. Conclusions. We defined a serum level for MBL deficiency that can be used with confidence in future studies of MBL disease associations. The risk of death was increased among MBL-deficient patients with severe pneumococcal infection, highlighting the pathogenic significance of this innate immune defence protein.
has issue date	2008-08-15(xsd:dateTime)
bibo:doi	10.1086/590006
bibo:pmid	18611155
has license	no-cc
sha1sum (hex)	0223acccc42f22041b56648a386d0f043322bf3d
schema:url	https://doi.org/10.1086/590006
resource representing a document's title	Low Serum Mannose-Binding Lectin Level Increases the Risk of Death due to Pneumococcal Infection
has PubMed Central identifier	PMC7107952
has PubMed identifier	18611155
schema:publication	Clin Infect Dis
resource representing a document's body	covid:0223acccc42f22041b56648a386d0f043322bf3d#body_text
is schema:about of	named entity 'MBL2' named entity 'LEVEL' named entity 'STUDIES' named entity 'DEFINED' named entity 'MANNOSE-BINDING LECTIN' named entity 'SUSCEPTIBILITY' named entity 'MBL DEFICIENCY' named entity 'ANALYSIS' named entity 'MANNOSE-BINDING LECTIN LEVEL' named entity 'DUE TO' named entity 'LOW' named entity 'PREVIOUS' named entity 'GENOTYPE' named entity 'VARIANT' named entity 'SEPSIS' named entity 'INCREASES' named entity 'DEATH' named entity 'SERUM' named entity 'RISK OF' named entity 'ASSOCIATIONS' named entity 'PNEUMOCOCCAL INFECTION' named entity 'HAVE' named entity 'LOW' named entity 'OUTCOMES' covid:arg/0223acccc42f22041b56648a386d0f043322bf3d named entity 'MBL2' named entity 'analysis' named entity 'MBL' named entity 'MBL deficiency' named entity 'multivariable analysis' named entity 'MBL' named entity 'genotypes' named entity 'power calculation' named entity 'MBL deficiency' named entity 'serum' named entity 'bacterial infection' named entity 'MBL deficiency' named entity 'MBL2' named entity 'sepsis' named entity 'multivariable analysis' named entity 'sepsis' named entity 'genotypes' named entity 'lectin complement pathway' named entity 'genotype' named entity 'MBL2' named entity 'risk of death' named entity 'pneumococcal infection' named entity 'receiver operating characteristic analysis' named entity 'Hardy-Weinberg' named entity 'MBL2' named entity 'MBL2' named entity 'multivariable analysis' named entity 'serum levels' named entity 'sepsis' named entity 'MBL deficiency' named entity 'Recombinant' named entity 'genotypes' named entity 'IL-6' named entity 'MBL deficiency' named entity 'serum' named entity 'serum' named entity 'mannan' named entity 'bacteremia'

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