About: Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains

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About: Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains
Creator	He, Qigai Xiao, Shaobo Peng, Guiqing Ye, Gang Deng, Feng Li, Youwen Liu, Qianqian Wan, Chunyun Zhong, Xiaoli Fu, Zhen Tariq Navid, Muhammad
Source	Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV), a member of Alphacoronavirus, has caused huge economic losses for the global pork industry recently. The spike (S) protein mediates PEDV entry into host cells. Herein, we investigated the interactions between the S protein and its receptor porcine aminopeptidase N (pAPN) or co-receptor sugars. The C-terminal domain (CTD) of the S1 domain is bound to pAPN. The prototype strain demonstrated similar receptor-binding activity compared with the variant field isolate. Three loops at the tips of the β-barrel domains did not play crucial roles in the PEDV S-pAPN association, indicating that PEDV conforms to a different receptor recognition model compared with transmissible gastroenteritis virus (TGEV), porcine respiratory CoV (PRCV), and human coronavirus NL63 (HCoV-NL63). The N-terminal domain (NTD) of the PEDV S1 domain could bind sugar, a possible co-receptor for PEDV. The prototype strain exhibited weaker sugar-binding activity compared with the variant field isolate. Strategies targeting the receptor binding domain (RBD) may be helpful for developing vaccines or antiviral drugs for PEDV. Understanding the differences in receptor binding between the prototype and the variant strains may provide insight into PEDV pathogenesis.
has issue date	2016-02-23(xsd:dateTime)
bibo:doi	10.3390/v8030055
bibo:pmid	26907329
has license	cc-by
sha1sum (hex)	021144f6c1945b9bff9ea9e4b04b24dcf53330b4
schema:url	https://doi.org/10.3390/v8030055
resource representing a document's title	Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains
has PubMed Central identifier	PMC4810246
has PubMed identifier	26907329
schema:publication	Viruses
resource representing a document's body	covid:021144f6c1945b9bff9ea9e4b04b24dcf53330b4#body_text
is schema:about of	named entity 'PORCINE' named entity 'INDUSTRY' named entity 'HOST CELLS' named entity 'DIFFERENT' named entity 'PATHOGENESIS' named entity 'POSSIBLE' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'S PROTEIN' named entity 'C-TERMINAL' named entity 'ECONOMIC' named entity 'ROLES' named entity 'MODEL' named entity 'UNDERSTANDING' named entity 'BIND' named entity 'CONFORMS' named entity 'FIELD' named entity 'INDICATING' named entity 'RECEPTOR BINDING' named entity '28S' named entity 'Strategies' named entity 'cells' named entity 'isolate' named entity 'industry' named entity 'play' named entity 'porcine' named entity 'Receptor' named entity 'COMPARISON' named entity 'BARREL ' named entity 'HUGE' named entity 'PROTOTYPE' named entity 'MEMBER OF' named entity 'GLOBAL' named entity 'PROTEIN ' named entity 'ANTIVIRAL DRUGS' named entity 'PROVIDE' named entity 'STRAIN' named entity 'INVESTIGATED' named entity 'HELPFUL' named entity 'DEMONSTRATED' named entity 'DID' named entity 'ENTRY INTO HOST' named entity 'BOUND' named entity 'VACCINES' named entity 'IDENTIFICATION' named entity 'PROTEIN ' named entity 'SPIKE PROTEIN' covid:arg/021144f6c1945b9bff9ea9e4b04b24dcf53330b4 named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'SPIKE' named entity 'COMPARED' named entity 'MEDIATES' named entity 'RECENTLY' named entity 'ASSOCIATION' named entity 'PORK' named entity 'AMINOPEPTIDASE N' named entity 'INSIGHT' named entity 'TARGETING' named entity 'DEVELOPING' named entity 'VARIANT' named entity 'RECEPTOR RECOGNITION' named entity 'SUGARS' named entity 'RECEPTOR' named entity 'HUMAN CORONAVIRUS NL63' named entity 'NL63' named entity 'CAUSED' named entity 'LOOPS' named entity 'PLAY' named entity 'CHARACTERISTICS' named entity 'RECEPTOR BINDING' named entity 'STRAINS' named entity 'TIPS'

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