About: A tripartite ssDNA mycovirus from a plant pathogenic fungus is infectious as cloned DNA and purified virions

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A tripartite ssDNA mycovirus from a plant pathogenic fungus is infectious as cloned DNA and purified virions
Creator	Zhou, Xueping Li, Pengfei Guo, Lihua Qiu, Dewen Wang, Shuangchao Zhang, Lihang
Source	Medline; PMC
abstract	Here, we describe a tripartite circular single-stranded (ss) DNA mycovirus, named Fusarium graminearum gemytripvirus 1 (FgGMTV1). The genome of FgGMTV1 comprises three circular ssDNA segments (DNA-A, DNA-B, and DNA-C). Sequence alignments and phylogenetic analyses showed that FgGMTV1 is nested within the family Genomoviridae. We also constructed the first infectious DNA clones of a DNA mycovirus. Our results show that DNA-A and DNA-B are mutually interdependent for their replication and are associated with severely reduced colony growth and hypovirulence. DNA-C relies on DNA-A and DNA-B for replication and is necessary for the recovery of abnormal fungal phenotypes. DNA-C also enhances the accumulation of viral DNA in infected fungi and permits stable colonization and easy transmission via conidia. This is the first multipartite DNA virus isolated from a fungus. Our phylogenetic analyses also suggest that the multipartite genome of FgGMTV1 may have evolved from a monopartite genome of an ancient genomovirus.
has issue date	2020-04-03(xsd:dateTime)
bibo:doi	10.1126/sciadv.aay9634
bibo:pmid	32284975
has license	cc-by-nc
sha1sum (hex)	01d772a6a9422d1200ec1511d011fffa4af11f19
schema:url	https://doi.org/10.1126/sciadv.aay9634
resource representing a document's title	A tripartite ssDNA mycovirus from a plant pathogenic fungus is infectious as cloned DNA and purified virions
has PubMed Central identifier	PMC7138691
has PubMed identifier	32284975
schema:publication	Sci Adv
resource representing a document's body	covid:01d772a6a9422d1200ec1511d011fffa4af11f19#body_text
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