About: COVID-19 Infection in Kidney Transplant Recipients: A Single-Center Case Series of 22 Cases From Belgium

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: COVID-19 Infection in Kidney Transplant Recipients: A Single-Center Case Series of 22 Cases From Belgium Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19 Infection in Kidney Transplant Recipients: A Single-Center Case Series of 22 Cases From Belgium
Creator	Belkhir, Leila De Greef, Julien Yombi, Jean-Cyr De Meyer, Martine Devresse, Arnaud Ghaye, Benoit Goffin, Eric Kabamba, Benoit Kanaan, Nada Mourad, Michel Scohy, Anaïs Vo, Bernard
Source	Elsevier; Medline; PMC
abstract	RATIONALE & OBJECTIVE: The world is facing a global pandemic caused by Sars-CoV-2 virus. Although kidney transplant recipients are at increased risk of viral infections, the impact of their chronic immunosuppressed status on the risk of acquiring coronavirus disease 2019 (COVID-19) and disease severity is unknown. STUDY DESIGN: All cases of COVID-19 infection in our cohort of kidney transplant recipients were prospectively monitored. Clinical features, management and outcomes were recorded. A standard strategy of immunosuppression minimization was applied: discontinue the antimetabolite drug and reduce trough levels of calcineurin or mTOR inhibitors. Unless contraindicated, hydroxychloroquine was administered only to hospitalized patients. SETTING & PARTICIPANTS: 22 COVID-19 infections were diagnosed in our cohort of 1200 kidney transplant recipients. RESULTS: Most common initial symptoms included fever, cough, or dyspnea. Eighteen patients (82%) required hospitalization. Of those patients, 3 had everolimus-based immunosuppression. Chest computerized tomography (CT) at admission (performed in 15 patients) showed mild (n=3), moderate (n=8), extensive (n=1), severe (n=2), and critical (n=1) involvement. Immunosuppression reduction was initiated in all patients. Hydroxychloroquine was administered to 15 patients. Eleven patients required supplemental oxygen; 2 of them were admitted to an intensive care unit (ICU) with mechanical ventilation. After a median of 10 days, 13 kidney transplant recipients were discharged, 2 were hospitalized in non- ICU, 1 was in ICU, and 2 patients had died. LIMITATIONS: Small sample size and short follow-up. CONCLUSIONS: Clinical presentation of COVID-19 infection was similar to that reported in the general population. A standard strategy of immunosuppression minimization and treatment was applied, with 11% mortality among kidney transplant recipients hospitalized with COVID-19.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1016/j.xkme.2020.06.001
bibo:pmid	32775986
has license	no-cc
sha1sum (hex)	01b169e991a3c88225697f477700df334405d4dd
schema:url	https://doi.org/10.1016/j.xkme.2020.06.001
resource representing a document's title	COVID-19 Infection in Kidney Transplant Recipients: A Single-Center Case Series of 22 Cases From Belgium
has PubMed Central identifier	PMC7295531
has PubMed identifier	32775986
schema:publication	Kidney Med
resource representing a document's body	covid:01b169e991a3c88225697f477700df334405d4dd#body_text
is schema:about of	named entity 'COVID-19' named entity 'Case' named entity 'PANDEMIC' named entity 'caused' named entity 'Infection' named entity 'Infection' named entity 'Kidney Transplant' named entity 'COVID' named entity 'infection' named entity 'CT-scan' named entity 'ethics committee' named entity 'acute rejection' named entity 'immunosuppression' named entity 'immunosuppression' named entity 'invasive ventilation' named entity 'co-morbidities' named entity 'malignancy' named entity 'kidney transplant' named entity 'infection' named entity 'general population' named entity 'Adjunctive treatment' named entity 'CRP' named entity 'trough level' named entity 'emergency department' named entity 'informed consent' named entity 'azathioprine' named entity 'acute pyelonephritis' named entity 'Tacrolimus' named entity 'palliative' named entity 'pneumonia' named entity 'kidney transplant' named entity 'respiratory illness' named entity 'supplemental oxygen' named entity 'tocilizumab' named entity 'rates of infection' named entity 'China' named entity 'terminally ill' named entity 'Case reports' named entity 'serum creatinine' named entity 'COVID-19' named entity 'infection' named entity 'antibiotics' named entity 'mortality rates' named entity 'symptom' named entity 'CRP' named entity 'tacrolimus' named entity 'COVID -19' named entity 'kidney transplant' named entity 'fever' named entity 'herpes zoster' named entity 'contra-indication' named entity 'stay at home' named entity 'hypercapnia' named entity 'acute rejection' named entity 'Mycophenolate' named entity 'invasive ventilation' named entity 'follow-up' named entity 'dialysis' named entity 'intensive care unit' named entity 'acute confusion' named entity 'dyspnea' named entity 'Belgian' named entity 'MERS' named entity 'CT scan' named entity 'hydroxychloroquine' named entity 'mortality rate' named entity 'CT-scan' named entity 'viral load' named entity 'mycophenolate' named entity 'Clinical features'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software