About: Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats

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About: Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats
Creator	Holmdahl, Rikard Saxne, Tore Vingsbo-Lundberg, Carina Olsson, Henric
topic	covid:01207321329715e944d0ae2cba853b919340ad91#this
Source	PMC
abstract	OBJECTIVE: To investigate the utility of serum cartilage oligomeric matrix protein (COMP) for disease monitoring in rats with chronic pristane‐induced arthritis, and to examine the influence of age, sex, and genes on COMP concentrations in rat serum. METHODS: Serum COMP levels were quantified by immunoassay. Sera were obtained from DA, E3, and (E3 × DA)F(1) rats each week between the ages of 4 and 30 weeks. The (E3 × DA)F(2) (second generation after intercrossing) rats were injected intradermally with the synthetic oil pristane. Arthritis was monitored by a macroscopic scoring system, and serum levels of COMP were measured on days 6, 35, and 49 after immunization. RESULTS: Serum levels of COMP decreased during growth, and reached a plateau after the age of 12 weeks. The DA rats had higher COMP levels than the E3 rats, and the (E3 × DA)F(1) rats had intermediate levels. No differences were observed in these levels when the rats were grouped by sex. Arthritic (E3 × DA)F(2) rats had increased serum concentrations of COMP on days 35 and 49 after pristane injection (P < 0.0001 versus the nonarthritic animals). COMP levels correlated with the severity of macroscopically detectable arthritis at both time points (r > 0.9). Rats with a chronic disease course were distinguished by higher serum concentrations of COMP during the acute stage than animals with similar clinical scores but with resolving arthritis (P < 0.01). CONCLUSION: Serum analyses of COMP offer promise for monitoring tissue involvement in experimental arthritis. Such analyses should be useful for monitoring therapeutic interventions aimed at retarding tissue destruction as well as for studies of the genetically determined regulation of COMP turnover and susceptibility to arthritis. The application of molecular marker measurements to experimental arthritis offers a new possibility for verifying the utility of such measurements in human arthritis.
has issue date	2004-05-28(xsd:dateTime)
bibo:doi	10.1002/1529-0131(199803)41:3<544::aid-art21>3.0.co;2-#
bibo:pmid	9506583
has license	no-cc
sha1sum (hex)	01207321329715e944d0ae2cba853b919340ad91
schema:url	https://doi.org/10.1002/1529-0131%28199803%2941:3%3C544::aid-art21%3E3.0.co%3B2-#
resource representing a document's title	Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats
has PubMed Central identifier	PMC7159671
has PubMed identifier	9506583
schema:publication	Arthritis Rheum
resource representing a document's body	covid:01207321329715e944d0ae2cba853b919340ad91#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/01207321329715e944d0ae2cba853b919340ad91
is schema:about of	named entity 'serum' named entity 'TO EXAMINE' named entity 'UTILITY' named entity 'CHRONIC' named entity 'cartilage oligomeric matrix protein' named entity 'antiserum' named entity 'cartilage' named entity 'arthritis' named entity 'joint diseases' named entity 'rat' named entity 'pristane' named entity 'COMP' named entity 'Hantaan virus' named entity 'synovial fluid' named entity 'pannus' named entity 'arthritis' named entity 'arthritis' named entity 'COMP' named entity 'arthritic' named entity 'monoclonal antibody' named entity 'arthritis' named entity 'serum concentrations' named entity 'thrombospondins' named entity 'EDTA' named entity 'SDS-PAGE' named entity 'antibody' named entity 'Sendai virus' named entity 'cartilage' named entity 'Pristane' named entity 'joint inflammation' named entity 'COMP' named entity 'revolutions per minute' named entity 'serum levels' named entity 'pristane' named entity 'Pharmacia' named entity 'Joint cartilage' named entity '0.01' named entity 'inflammation' named entity 'COMP' named entity 'cartilage' named entity 'cartilage' named entity 'resuspension' named entity 'COMP' named entity 'COMP' named entity 'rat' named entity 'COMP' named entity 'Beckman Instruments' named entity 'COMP' named entity 'epitopes' named entity 'COMP' named entity 'DEAE-Sepharose' named entity 'serum' named entity 'serum concentrations' named entity 'COMP' named entity 'articular cartilage' named entity 'rat' named entity '0.01' named entity 'COMP' named entity 'Arthritis' named entity 'EDTA' named entity 'dialyzed' named entity 'COMP' named entity 'pathogens' named entity 'COMP' named entity 'macroscopic' named entity 'antibody' named entity 'inflammatory cells' named entity 'serum' named entity 'extracellular matrix' named entity 'serum levels' named entity 'Immunoassay' named entity 'COMP' named entity 'COMP' named entity 'COMP' named entity 'serum concentrations' named entity 'serum'

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