About: The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study

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About: The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study
Creator	Laffey, John Mcauley, Danny Shankar-Hari, Manu Harrison, David Mcguigan, Peter
Source	PMC
abstract	BACKGROUND: Outcomes following out of hospital cardiac arrest (OHCA) are poor. The optimal arterial oxygen and carbon dioxide (PaCO(2)) levels for managing patients following OHCA are unknown. We hypothesized that abnormalities in arterial oxygenation (PaO(2)/FiO(2) ratio or PaO(2)) and PaCO(2) would be associated with hospital mortality following OHCA. We hypothesized that PaCO(2) would significantly modify the oxygenation–mortality relationship. METHODS: This was an observational cohort study using data from OHCA survivors admitted to adult critical care units in England, Wales and Northern Ireland from 2011 to 2018. Logistic regression analyses were performed to assess the relationship between hospital mortality and oxygenation and PaCO(2). RESULTS: The analysis included 23,625 patients. In comparison with patients with a PaO(2)/FiO(2) > 300 mmHg, those with a PaO(2)/FiO(2) ≤ 100 mmHg had higher mortality (adjusted OR, 1.79; 95% CI, 1.48 to 2.15; P < 0.001). In comparison to hyperoxemia (PaO(2) > 100 mmHg), patients with hypoxemia (PaO(2) < 60 mmHg) had higher mortality (adjusted OR, 1.34; 95% CI, 1.10 to 1.65; P = 0.004). In comparison with normocapnia, hypercapnia was associated with lower mortality. Hypocapnia (PaCO2 ≤ 35 mmHg) was associated with higher mortality (adjusted OR, 1.91; 95% CI, 1.63 to 2.24; P < 0.001). PaCO(2) modified the PaO(2)/FiO(2)–mortality and PaO(2)–mortality relationships, though these relationships were complex. Patients who were both hyperoxic and hypercapnic had the lowest mortality. CONCLUSIONS: Low PaO(2)/FiO(2) ratio, hypoxemia and hypocapnia are associated with higher mortality following OHCA. PaCO(2) modifies the relationship between oxygenation and mortality following OHCA; future studies examining this interaction are required.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.1186/s13054-020-03039-6
has license	cc-by
sha1sum (hex)	0116454234b0b28edb90093532562a9b0251f335
schema:url	https://doi.org/10.1186/s13054-020-03039-6
resource representing a document's title	The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study
has PubMed Central identifier	PMC7290139
schema:publication	Crit Care
resource representing a document's body	covid:0116454234b0b28edb90093532562a9b0251f335#body_text
is schema:about of	named entity 'hospital' named entity 'oxygenation' named entity 'CARBON DIOXIDE' named entity 'MANAGING' named entity 'managing' named entity 'PaCO' named entity 'hospital' named entity 'hypoxemia' named entity 'Hypocapnia' named entity 'Adjusted odds ratio' named entity 'intensive care units' named entity 'Physiology' named entity 'Hypercapnia' named entity 'pathology' named entity 'logistic regression' named entity 'hyperoxia' named entity 'mmHg' named entity 'neurological' named entity 'logistic regression' named entity 'College Station, TX' named entity 'odds ratios' named entity 'cardiac arrest' named entity 'OHCA' named entity 'hypocapnia' named entity 'Adjusted odds ratio' named entity 'hypocapnia' named entity 'free radical' named entity 'hypoxemia' named entity 'Sensitivity analysis' named entity 'ICU' named entity 'myocardial ischaemia' named entity 'physiological parameters' named entity 'Sensitivity analysis' named entity 'co-morbidities' named entity 'Physiology' named entity 'mmHg' named entity 'mmHg' named entity 'APACHE II' named entity 'hypoxemia' named entity 'anti-oxidant' named entity 'pathology' named entity 'upper gastrointestinal bleeding' named entity 'hypercapnia' named entity 'systemic inflammation' named entity 'neuroprotective effects' named entity 'hypocapnia' named entity 'mmHg' named entity 'type II error' named entity 'MAP' named entity 'logistic regression' named entity 'ICU' named entity 'outcome measure' named entity 'residual confounding' named entity 'ICU' named entity 'statistically significant' named entity 'logistic regression' named entity 'Stata' named entity 'MAP' named entity 'cardiac arrest' named entity 'APACHE II' named entity 'hypercapnia' named entity 'cardiac arrest' named entity 'interaction' named entity 'oxygenation' named entity 'cohort study' named entity 'carbon dioxide' named entity 'cardiac arrest' named entity 'co-linearity' named entity 'cardiac arrest' named entity 'free radical' named entity 'hypoxemia' named entity 'causality' named entity 'hypoxemia' named entity 'pulmonary hypertension' named entity 'interquartile range' named entity 'hypercapnia' named entity 'neurological' named entity 'hypercapnia' named entity 'acidosis'

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