About: Genomic analysis of early SARS-CoV-2 strains introduced in Mexico

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genomic analysis of early SARS-CoV-2 strains introduced in Mexico
Creator	Perez-Padilla, Rogelio Escalera-Zamudio, Marina López, Susana Isa, Pavel Taboada, Blanca Arias, Becerril-Vargas, Eduardo Lucía, Aburto, Borja Araiza Rodríguez, Adnan Armando Vazquez-Perez, Joel Barrera Badillo, Gisela Boukadida, Celia Cervantes, Condado, Mendieta Ernesto Ramírez-González, José Garcés Ayala, Fabiola Gaytán-Cervantes, Francisco González-Torres, Carolina Grajales Muñiz, Concepción Grande, Ricardo Hugo, Víctor López Martínez, Irma Martínez-Orozco, Arturo Medina, Esteban Pulido, Francisco Ramos, Pilar Raúl González Bonilla, Cesar Rivas, Hernández Ruiz-9 Palacios, Guillermo Salas-Hernández, Jorge Sanchez-Flores, Alejandro Vazquez, Gloria
Source	BioRxiv
abstract	The COVID-19 pandemic has affected most countries in the world. Studying the evolution and transmission patterns in different countries is crucial to implement effective strategies for disease control and prevention. In this work, we present the full genome sequence for 17 SARS-CoV-2 isolates corresponding to the earliest sampled cases in Mexico. Global and local phylogenomics, coupled with mutational analysis, consistently revealed that these viral sequences are distributed within 2 known lineages, the SARS-CoV-2 lineage A/G, containing mostly sequences from North America, and the lineage B/S containing mainly sequences from Europe. Based on the exposure history of the cases and on the phylogenomic analysis, we characterized fourteen independent introduction events. Additionally, three cases with no travel history were identified. We found evidence that two of these cases represent local transmission cases occurring in Mexico during mid-March 2020, denoting the earliest events described in the country. Within this Mexican cluster, we also identified an H49Y amino acid change in the spike protein. This mutation is a homoplasy occurring independently through time and space, and may function as a molecular marker to follow on any further spread of these viral variants throughout the country. Our results depict the general picture of the SARS-CoV-2 variants introduced at the beginning of the outbreak in Mexico, setting the foundation for future surveillance efforts. This work is the result of the collaboration of five institutions into one research consortium: three public health institutes and two universities. From the beginning of this work, it was agreed that the experimental leader of each institution would share the first authorship. Those were the criteria followed to assign first co-first authorship in this manuscript. The order of the other authors was randomly assigned. IMPORTANCE Understanding the introduction, spread and establishment of SARS-CoV-2 within distinct human populations is crucial to implement effective control strategies as well as the evolution of the pandemics. In this work, we describe that the initial virus strains introduced in Mexico came from Europe and the United States and the virus was circulating locally in the country as early as mid-March. We also found evidence for early local transmission of strains having the mutation H49Y in the Spike protein, that could be further used as a molecular marker to follow viral spread within the country and the region.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.1101/2020.05.27.120402
has license	biorxiv
sha1sum (hex)	00f442d557df9be627dbc3cf185df28116587af6
schema:url	https://doi.org/10.1101/2020.05.27.120402
resource representing a document's title	Genomic analysis of early SARS-CoV-2 strains introduced in Mexico
schema:publication	bioRxiv
resource representing a document's body	covid:00f442d557df9be627dbc3cf185df28116587af6#body_text
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