About: An integrated perfusion machine preserves injured human livers for 1 week

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An integrated perfusion machine preserves injured human livers for 1 week
Creator	Becker, Dustin Clavien, Pierre-Alain Dutkowski, Philipp Eshmuminov, Dilmurodjon Graf, Rolf Hagedorn, Catherine Hefti, Max Mueller, Matteo Muller, Xavier Onder, Christopher Schuler, Martin Weber, Achim Borrego, Lucia Rohr, Von Rudolf Von Rohr, Philipp Rudolf, Philipp
Source	PMC
abstract	The ability to preserve metabolically active livers ex vivo for 1 week or more could allow repair of poor-quality livers that would otherwise be declined for transplantation. Current approaches for normothermic perfusion can preserve human livers for only 24 h. Here we report a liver perfusion machine that integrates multiple core physiological functions, including automated management of glucose levels and oxygenation, waste-product removal and hematocrit control. We developed the machine in a stepwise fashion using pig livers. Study of multiple ex vivo parameters and early phase reperfusion in vivo demonstrated the viability of pig livers perfused for 1 week without the need for additional blood products or perfusate exchange. We tested the approach on ten injured human livers that had been declined for transplantation by all European centers. After a 7-d perfusion, six of the human livers showed preserved function as indicated by bile production, synthesis of coagulation factors, maintained cellular energy (ATP) and intact liver structure.
has issue date	2020-01-13(xsd:dateTime)
bibo:doi	10.1038/s41587-019-0374-x
bibo:pmid	31932726
has license	no-cc
sha1sum (hex)	00ea431edaa5e65aa06c32bc187dfdfbcb9d6789
schema:url	https://doi.org/10.1038/s41587-019-0374-x
resource representing a document's title	An integrated perfusion machine preserves injured human livers for 1 week
has PubMed Central identifier	PMC7008032
has PubMed identifier	31932726
schema:publication	Nat Biotechnol
resource representing a document's body	covid:00ea431edaa5e65aa06c32bc187dfdfbcb9d6789#body_text
is schema:about of	named entity 'P-value' named entity 'LDH' named entity 'H&E' named entity 'liver' named entity 'bile' named entity 'blue line' named entity 'fibrosis' named entity 'black arrows' named entity 'pig' named entity 'BUN' named entity 'human liver' named entity 'Caspase 3' named entity 'CK7' named entity 'epithelial' named entity 'oxygen' named entity 'staining' named entity 'significant difference' named entity 'perfusion' named entity 'clinical setting' named entity 'perfusion' named entity 'Cholestasis' named entity 'Liver' named entity 'bile' named entity 'BUN' named entity 'Pig' named entity 'staining' named entity 'perfusion' named entity 'glycogen synthase' named entity 'ambient air' named entity 'Perfused' named entity 'portal vein' named entity 'Ki-67' named entity 'perfusion' named entity 'hepatocytes' named entity 'cell apoptosis' named entity 'perfusion' named entity 'liver' named entity 'insulin signaling pathway' named entity 'Perfused' named entity 'pig' named entity 'reperfusion' named entity 'endothelial cell activation' named entity 'liver' named entity 'necrotic' named entity 'bile' named entity 'cell death' named entity 'reperfusion' named entity 'perfusion' named entity 'pig' named entity 'Endothelial cells' named entity 'GSK3b' named entity 'histology' named entity 'Hypothermic' named entity 'Pig' named entity 'biopsied' named entity 'glycogen' named entity 'extrahepatic bile ducts' named entity 'total bilirubin' named entity 'Lactate' named entity 'insulin' named entity 'pig' named entity 'ICAM-1' named entity 'AST' named entity 'Western blot' named entity 'mitotic activity' named entity 'pig'

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