About: Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species
Creator	Li, Jing Qi, Jianxun Liu, Di Cao, Ying Ali, Ahmed Liu, Wenjun Kattoor, Jobin Bai, Zhihua Gong, Yue Sun, Yeping Tian, Xiaodong Gong, Bai
Source	Medline; PMC
abstract	Human beings are currently experiencing a serious public health event. Novel coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), has infected about 3 million people worldwide and killed more than 200,000, most being the elderly or people with potential chronic diseases or in immunosuppressive states. According to big data analysis, there are many proteins homologous to or interacting with the angiotensin-converting enzyme 2 (ACE2), which, therefore, may not be the only receptor for the novel coronavirus; other receptors may also exist in host cells of different species. These potential receptors may also play an important role in the infection process of the novel coronavirus. The current study aimed to discover such key proteins or receptors and analyze the susceptibility of different animals to the novel coronavirus, in order to reveal the transmission process of the virus in cross-species infection. We analyzed the proteins coded by the ACE2 gene in different mammalian species and predicted their correlation and homology with the human ACE2 receptor. The major finding of our predictive analysis suggested ACE2 gene-encoded proteins to be highly homologous across mammals. Based on their high homology, their possibility of binding the spike-protein of SARS-CoV-2 is quite high and species such as Felis catus, Bos taurus, Rattus norvegicus etc. may be potential susceptible hosts; special monitoring is particularly required for livestock that are in close contact with humans. Our results might provide ideas for the prevention and control of the novel coronavirus pneumonia.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.3389/fvets.2020.00457
bibo:pmid	32719819
has license	cc-by
sha1sum (hex)	00a71a90b4fb896291913c6d290833ade77e2aa1
schema:url	https://doi.org/10.3389/fvets.2020.00457
resource representing a document's title	Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species
has PubMed Central identifier	PMC7349190
has PubMed identifier	32719819
schema:publication	Front Vet Sci
resource representing a document's body	covid:00a71a90b4fb896291913c6d290833ade77e2aa1#body_text
is schema:about of	named entity 'infection' named entity 'receptors' named entity 'severe acute respiratory syndrome coronavirus' named entity 'pneumonia' named entity 'correlation' named entity 'key' named entity 'STATES' named entity 'REQUIRED' named entity 'OUR' named entity 'INFECTION' named entity 'SARS-COV-2' named entity 'interacting' named entity 'control' named entity 'exist' named entity 'peptide' named entity 'anti-fibrotic' named entity 'SARS-CoV-2' named entity 'amino acid' named entity 'ACE2' named entity 'ACE2' named entity 'livestock' named entity 'virus' named entity 'SARS-CoV-2' named entity 'C-terminal' named entity 'MERS-CoV' named entity 'RBD' named entity 'SARS-CoV-2' named entity 'livestock' named entity 'protein sequence' named entity 'Ang II' named entity 'immunosuppressive' named entity 'SARS-CoV' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'protein sequence' named entity 'Angiotensin-converting enzyme' named entity 'homology' named entity 'immune response' named entity 'decapeptide' named entity 'data analysis' named entity 'prevention and control' named entity 'ACE2' named entity 'severe acute respiratory syndrome coronavirus' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'N-terminal' named entity 'protein sequences' named entity 'mammalian species' named entity 'protease' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'gene' named entity 'immune recognition' named entity 'protein sequences' named entity 'Felis catus' named entity 'ACE2' named entity 'protein' named entity 'infectious disease' named entity 'vasodilator' named entity 'protein' named entity 'ACE2' named entity 'protein sequences' named entity 'mammals' named entity 'infection' named entity 'cross-species' named entity 'virus' named entity 'Needleman-Wunsch algorithm' named entity 'Ang II' named entity 'protein sequence' named entity 'homologous proteins' named entity 'ACE2'

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