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About:
Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy
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An Entity of Type :
schema:ScholarlyArticle
, within Data Space :
covidontheweb.inria.fr
associated with source
document(s)
Type:
Academic Article
research paper
schema:ScholarlyArticle
New Facet based on Instances of this Class
Attributes
Values
type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy
Creator
Baldanti, Fausto
Piralla, Antonio
Bianchini, Sonia
Caimmi, Silvia
Esposito, Susanna
Girello, Alessia
Lunghi, Giovanna
Principi, Nicola
Ruggiero, Luca
Giardina, Federica
De Sando, Elisabetta
Marseglia, Gian
topic
covid:0079559ab8717d83bc3df6be8533ff9672bb4367#this
Source
Elsevier; Medline; PMC
abstract
BACKGROUND: In recent years, several outbreaks due to Enterovirus D-68 (EV-D68) have been reported, and it was confirmed that the virus can cause upper and lower respiratory tract diseases and be associated with the development of neurological problems. OBJECTIVES: The main aim of this research was to study the genetic characteristics of EV-D68 strains that were circulating in Italy identified during an outbreak of an EV-D68 infection that occurred in Italy during the period March-October 2016. STUDY DESIGN: A retrospective study of the circulation of different types and subtypes of EV-D68 was performed. Nasopharyngeal swabs were collected from March 2016 through October 2016 in children admitted to the Emergency Room with respiratory diseases. RESULTS: Among 390 children, 22 (59.1% males; mean age 47 months) were found to be infected by EV-D68 and most of them were immunocompetent (72.7%). Pneumonia was diagnosed in 12 (54.5%) children. Phylogenetic analysis of the VP1 region showed that all the strains identified in this study belonged to clade B3. Within B3 subclade, the Italian EV-D68 strains were most closely related to strains detected in Southern China in 2015 as well as to strains detected in US and the Netherlands in 2016. CONCLUSIONS: These results showed that EV-D68 infections are a common cause of lower respiratory illness in pediatric age. The circulation of one EV-D68 lineage has been proven in Italy and in the European region during 2016. However, further studies are required to investigate whether some strains or lineages may possess a higher affinity for the lower airway or central nervous system.
has issue date
2018-01-12
(
xsd:dateTime
)
bibo:doi
10.1016/j.jcv.2018.01.005
bibo:pmid
29396353
has license
no-cc
sha1sum (hex)
0079559ab8717d83bc3df6be8533ff9672bb4367
schema:url
https://doi.org/10.1016/j.jcv.2018.01.005
resource representing a document's title
Enterovirus-D68 (EV-D68) in pediatric patients with respiratory infection: The circulation of a new B3 clade in Italy
has PubMed Central identifier
PMC7185653
has PubMed identifier
29396353
schema:publication
J Clin Virol
resource representing a document's body
covid:0079559ab8717d83bc3df6be8533ff9672bb4367#body_text
is
http://vocab.deri.ie/void#inDataset
of
https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/0079559ab8717d83bc3df6be8533ff9672bb4367
is
schema:about
of
named entity 'circulation'
named entity 'ENTEROVIRUS'
named entity 'ITALY'
named entity 'CIRCULATION'
named entity 'D68'
named entity 'NEW'
named entity 'RESPIRATORY INFECTION'
named entity 'PEDIATRIC'
named entity 'CLADE'
named entity 'PATIENTS'
named entity 'SLAC'
named entity 'clade'
named entity 'asthma'
named entity 'EV-D68'
named entity 'Homo sapiens'
named entity 'clades'
named entity 'RSV'
named entity 'QIAGEN'
named entity 'EV-D68'
named entity 'Italy'
named entity 'EV-D68'
named entity 'Hilden'
named entity 'clade'
named entity 'Milan'
named entity 'Emergency Room'
named entity 'clade'
named entity 'clades'
named entity 'amino acid'
named entity 'Italy'
named entity 'gene'
named entity 'acute flaccid paralysis'
named entity '2014 and 2015'
named entity 'EV-D68'
named entity 'viruses'
named entity 'VP1'
named entity 'EV-D68'
named entity 'genome sequences'
named entity 'SLAC'
named entity 'clades'
named entity 'Intensive Care Unit'
named entity 'hRV'
named entity 'diffusion'
named entity 'evolutionary origin'
named entity 'EV-D68'
named entity 'human coronavirus'
named entity 'Codon'
named entity 'EV-D68'
named entity 'infectious agent'
named entity 'molecular phylogeny'
named entity 'clade'
named entity 'EV-D68'
named entity 'EV-D68'
named entity 'infection'
named entity 'epidemiological'
named entity 'β-sheets'
named entity 'EV-D68'
named entity 'Netherlands'
named entity 'patients'
named entity 'clade'
named entity 'nucleotide substitution'
named entity 'maximum likelihood'
named entity 'amino acid'
named entity 'Japan'
named entity 'codons'
named entity 'neurological problems'
named entity 'EV-D68'
named entity 'clades'
named entity 'informed consent'
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