About: Observational Study of the Efficiency of Treatments in Patients Hospitalized with Covid-19 in Madrid

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Observational Study of the Efficiency of Treatments in Patients Hospitalized with Covid-19 in Madrid Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Observational Study of the Efficiency of Treatments in Patients Hospitalized with Covid-19 in Madrid
Creator	Bernaola, Ander Bernaola, Nikolas Bielza, Concha Carballo, Cesar Lara, Antonio Larrañaga, Pedro Mena, Raquel
Source	MedRxiv
abstract	Background Many different treatments were heavily administered to patients with COVID-19 during the peak of the pandemic in Madrid without robust evidence supporting them. Methods We examined the association between sixteen treatments in four groups (steroids, antivirals, antibiotics and immunomodulators) and intubation or death. Data were obtained from patients that were admitted to an HM hospital with suspicion of COVID-19 until 24/04/2020, excluding unconfirmed diagnosis, those who were admitted before the epidemic started in Madrid, had an outcome that was not discharge or death or died within 24 hours of presentation. We compared outcomes between treated and untreated patients using propensity-score caliper matching. Results Of 2,307 patients in the dataset, 679 were excluded. Of the remaining 1,645 patients, 263 (16%) died and 311 (18.9%) died or were intubated. Except for hydroxychloroquine and prednisone, patients that were treated with any of the medications were more likely to go through an outcome of death or intubation at baseline. After propensity matching we found an association between treatment with hydroxychloroquine and prednisone and better outcomes (hazard ratios with 95% CI of 0.83 +- 0.06 and 0.85 +- 0.03). Results were similar in multiple sensitivity analyses. Conclusions In this multicenter study of patients admitted with COVID-19 hydroxychloroquine and prednisone administration was found to be associated with improved outcomes. Other treatments were associated with no effect or worse outcomes. Randomized, controlled trials of these medications in patients with COVID-19 are needed to avoid heavy administration of treatments with no strong evidence to support them.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.1101/2020.07.17.20155960
has license	medrxiv
sha1sum (hex)	00647260b5a9bb71d29cddf9ce5ade8d9ce6b25b
schema:url	https://doi.org/10.1101/2020.07.17.20155960
resource representing a document's title	Observational Study of the Efficiency of Treatments in Patients Hospitalized with Covid-19 in Madrid
resource representing a document's body	covid:00647260b5a9bb71d29cddf9ce5ade8d9ce6b25b#body_text
is schema:about of	named entity 'pandemic' named entity 'PATIENTS' named entity 'ADMINISTERED' named entity 'TREATMENTS' named entity 'Madrid' named entity 'Madrid' named entity 'COVID' named entity 'CC-BY-NC 4.0' named entity 'COVID-19' named entity 'Madrid' named entity 'oseltamivir' named entity 'missing data' named entity 'Europe' named entity 'heart rate' named entity 'statistically significant' named entity 'D-dimer' named entity 'COVID' named entity 'hydroxychloroquine' named entity 'Diastolic blood pressure' named entity 'penicillin' named entity 'COVID-19' named entity 'peer review' named entity 'current literature' named entity 'ferritin' named entity 'prednisone' named entity 'China' named entity 'CC-BY-NC 4.0' named entity 'amoxicillin' named entity 'hydrocortisone' named entity 'ICU' named entity 'statistical significance' named entity 'CC-BY-NC 4.0' named entity 'azithromycin' named entity 'A2a' named entity 'Many' named entity 'Madrid' named entity 'multiple comparisons' named entity 'COVID' named entity 'immunomodulators' named entity 'significant effect' named entity 'CC-BY-NC 4.0' named entity 'medRxiv' named entity 'hydroxychloroquine' named entity 'Chi-square tests' named entity 'ined' named entity 'risk factors' named entity 'hydroxychloroquine' named entity 'Neutrophil' named entity 'COVID' named entity 'COVID' named entity 'prednisone' named entity 'vital signs' named entity 'hydroxychloroquine' named entity 'interferon beta 1b' named entity 'COVID' named entity 'medRxiv' named entity 'controlled trials' named entity 'confidence intervals' named entity 'intubation' named entity 'vital signs' named entity 'hydroxychloroquine' named entity 'diabetes' named entity 'numpy' named entity 'piperacillin' named entity 'hydroxychloroquine' named entity 'intubation' named entity 'probability' named entity 'lymphocyte count' named entity '4.7' named entity 'COVID' named entity 'chronic obstructive pulmonary disease' named entity 'prednisone' named entity 'hypertension' named entity 'prednisone' named entity 'hypercholesterolemia' named entity '95% CI' named entity 'Viral load' named entity 'ischaemic events' named entity 'confidence intervals'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software