About: Long‐term morbidity of respiratory viral infections during chemotherapy in children with leukaemia

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About: Long‐term morbidity of respiratory viral infections during chemotherapy in children with leukaemia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Long‐term morbidity of respiratory viral infections during chemotherapy in children with leukaemia
Creator	Hardaker, Kate Lin, Beryl Ng, Anthea Robinson, Paul Widger, John Coward Bclinexerphys, Emma Geoffrey, \| Gradcertprs, Jamie Hiran, \| Jaffe, \| Kennedy Bsc, Brendan Leanne, \| Luciano, \| Mbbs, Dalla-Pozza Mbbs, Mccowage Mbbs, Selvadurai Mbbs, Trahair Toby, \|
Source	PMC
abstract	BACKGROUND: Respiratory viruses are a common cause of infection in immunosuppressed children undergoing cancer therapy. Pulmonary sequelae have been documented following respiratory viral infections (RVIs) in hematopoietic stem cell transplant (HSCT) recipients; however potential late effects in children undergoing nonmyeloablative chemotherapy have not been investigated. AIM: To evaluate the long‐term pulmonary morbidity of respiratory viral infections during chemotherapy in children with acute lymphoblastic leukemia (ALL). METHODS: Childhood ALL survivors, aged 7 to 18 years, greater than 6 months posttreatment were recruited. Exclusion criteria included HSCT or proven bacterial/fungal respiratory infection during treatment. Subjects were classified into “viral” or “control” groups according to retrospective medical records that documented the presence of laboratory‐proven RVIs during chemotherapy. Symptom questionnaires (Liverpool, ISAAC) and lung function testing (spirometry, plethysmography, diffusing capacity, forced oscillation technique to ATS/ERS standards) were then performed cross‐sectionally at the time of recruitment. RESULTS: Fifty‐four patients (31 viral, 23 control) were recruited: median (range) age 11.2 (7.2‐18.1) years, and at 4.9 (0.5‐13) years posttherapy. Abnormalities were detected in 17 (31%) individuals (8 viral, 9 control), with the most common being DLCO impairment (3 viral, 4 control) and reduced respiratory reactance at 5 Hz (5 viral, 6 control). Children with RVIs during chemotherapy reported more current respiratory symptoms, particularly wheeze (odds ratio [OR], 3.0; 95% confidence interval [CI]: 0.9‐10.0; P = .09) and cough (OR, 2.7; 95% CI: 0.8‐9.5; P = .11). No differences in lung function tests were observed between the two groups. CONCLUSIONS: Our study found children with RVIs during chemotherapy developed more long‐term respiratory symptoms than controls; however, differences did not reach statistical significance. No differences in static lung function were found between the two groups. Overall, pulmonary abnormalities and/or significant ongoing respiratory symptoms were detected in nearly a third of ALL survivors treated without HSCT. Larger, prospective studies are warranted to evaluate the etiology and clinical significance of these findings.
has issue date	2019-08-08(xsd:dateTime)
bibo:doi	10.1002/ppul.24456
bibo:pmid	31393087
has license	no-cc
sha1sum (hex)	0050cb5ead95958706cd183ab1115e70c6a626ba
schema:url	https://doi.org/10.1002/ppul.24456
resource representing a document's title	Long‐term morbidity of respiratory viral infections during chemotherapy in children with leukaemia
has PubMed Central identifier	PMC7167615
has PubMed identifier	31393087
schema:publication	Pediatr Pulmonol
resource representing a document's body	covid:0050cb5ead95958706cd183ab1115e70c6a626ba#body_text
is schema:about of	named entity 'pulmonary' named entity 'Respiratory' named entity 'chemotherapy' named entity 'HEMATOPOIETIC STEM CELL' named entity 'MORBIDITY' named entity 'HAVE' named entity 'STEM CELL TRANSPLANT' named entity 'RESPIRATORY VIRUSES' named entity 'Fisher's exact test' named entity 'viruses' named entity 'lung function' named entity 'etiology' named entity 'informed consent' named entity 'Demographic' named entity 'immunofluorescence' named entity 'chemotherapy' named entity 'bronchodilator' named entity 'wheeze' named entity 'Sydney Children's Hospitals Network' named entity 'prognosis' named entity 'long-term' named entity 'viral infections' named entity 'pulmonary abnormalities' named entity 'inflammatory responses' named entity 'leukemia' named entity 'DLCO' named entity 'morbidity' named entity 'bacterial infections' named entity 'HMPV' named entity 'statistical significance' named entity 'Sydney Children's Hospitals Network' named entity 'viral infections' named entity 'statistical significance' named entity 'morbidity' named entity 'acute lymphoblastic leukemia' named entity 'respiratory infections' named entity 'acute lymphoblastic leukemia' named entity 'infection' named entity 'respiratory viral infections' named entity 'sequelae' named entity 'morbidity' named entity 'respiratory viral infections' named entity 'hematopoietic stem cell' named entity 'clinical characteristics' named entity 'respiratory infections' named entity 'pediatric' named entity 'childhood cancers' named entity 'pulmonary abnormalities' named entity 'chemotherapy' named entity 'Children's Oncology Group' named entity 'acute lymphoblastic leukemia' named entity 'lung' named entity 'chemotherapy' named entity 'long-term' named entity 'pathogenesis' named entity 'statistically significant' named entity 'childhood cancer' named entity 'viruses' named entity 'type II error' named entity 'cough' named entity 'follow-up' named entity 'precipitate' named entity 'sequelae' named entity 'HRV'

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