About: Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques
Creator	Peng, Cheng Shi, Zheng-Li Yang, Xing-Lou Zhou, Peng Chen, Ying Yuan, Zhi-Ming Jiang, Ren-Di Shan, Chao Wang, Yan-Yi Yang, Lian Hu, Xue Wu, Jia Si, Hao-Rui Pang, Wei Xiong, Jin Zhang, Hua-Jun Zheng, Yong-Tang Gao, Ge Gao, Xiao-Xiao Hu, Zheng-Fei Lv, Long-Bao Min, Juan Peng, Yun Wei, Hong-Ping Yao, Yan-Feng Zhou, Yi-Wu
Source	Medline; PMC
abstract	The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health. SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases, with a mortality rate of ~6.4% worldwide (based on World Health Organization daily situation report). However, the dynamics of viral infection, replication and shedding are poorly understood. Here, we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2. After intratracheal inoculation, the first peak of viral RNA was observed in oropharyngeal swabs one day post infection (1 d.p.i.), mainly from the input of the inoculation, while the second peak occurred at 5 d.p.i., which reflected on-site replication in the respiratory tract. Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals, characterized by hyperemia and edema, and infiltration of monocytes and lymphocytes in alveoli. We also identified SARS-CoV-2 RNA in respiratory tract tissues, including trachea, bronchus and lung; and viruses were also re-isolated from oropharyngeal swabs, bronchus and lung, respectively. Furthermore, we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2. The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics.
has issue date	2020-07-07(xsd:dateTime)
bibo:doi	10.1038/s41422-020-0364-z
bibo:pmid	32636454
has license	cc-by
sha1sum (hex)	004f9dd34959cb180b137043400063c71b8796eb
schema:url	https://doi.org/10.1038/s41422-020-0364-z
resource representing a document's title	Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques
has PubMed Central identifier	PMC7364749
has PubMed identifier	32636454
schema:publication	Cell Res
resource representing a document's body	covid:004f9dd34959cb180b137043400063c71b8796eb#body_text
is schema:about of	named entity 'demonstrated' named entity 'evaluate' named entity 'identified' named entity 'Here' named entity 'replication' named entity 'peak' named entity 'inoculation' named entity 'infection' named entity 'pneumonia' named entity 'SARS-COV-2' named entity 'CLINICAL' named entity 'SITE' named entity 'PUBLIC HEALTH' named entity 'INFILTRATION' named entity 'PEAK' named entity 'POORLY' named entity 'OUTBREAK' named entity 'SARS-COV-2 INFECTION' named entity 'VIRAL INFECTION' named entity 'HUMAN' named entity 'OCCURRED' named entity 'CHARACTERIZED' named entity 'REPORT' named entity 'CASES' named entity 'MONOCYTES' named entity 'LYMPHOCYTES' named entity 'NON-HUMAN PRIMATE' named entity 'CAUSE' named entity 'ONE DAY' named entity 'SARS-COV-2 RNA' named entity 'WORLDWIDE' named entity 'viruses' named entity 'BSA' named entity 'SARS-CoV-2' named entity 'China' named entity 'SARS-CoV-2' named entity 'whole-genome sequencing' named entity 'pathological examination' named entity 'infection' named entity 'clinical signs' named entity 'viral infection' named entity 'alveolar' named entity 'ACE2' named entity 'supernatant' named entity 'necrosis' named entity 'kidney' named entity 'sputum production' named entity 'bronchioles' named entity 'incubation' named entity 'supernatant' named entity 'aerosols' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'SARS-CoV-2' named entity 'staining' named entity 'respiratory tract' named entity 'oropharyngeal'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software