About: La, PTB, and PAB proteins bind to the 3′ untranslated region of Norwalk virus genomic RNA

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About: La, PTB, and PAB proteins bind to the 3′ untranslated region of Norwalk virus genomic RNA Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	La, PTB, and PAB proteins bind to the 3′ untranslated region of Norwalk virus genomic RNA
Creator	Escobar-Herrera, Jaime Guti E Errez-Escolano, Ana Hern A Andez-Acosta, Javier V A Azquez-Ochoa, Melina
topic	covid:003f719a05b7a35ea4b778ded17cae230f5a0343#this
Source	Elsevier; Medline; PMC
abstract	Abstract Noroviruses are human enteric caliciviruses for which no cell culture is available. Consequently, the mechanisms and factors involved in their replication have been difficult to study. In an attempt to analyze the cis- and trans-acting factors that could have a role in NV replication, the 3′-untranslated region of the genome was studied. Use of Zuker’s mfold-2 software predicted that NV 3′UTR contains a stem-loop structure of 47 nts. Proteins from HeLa cell extracts, such as La and PTB, form stable complexes with this region. The addition of a poly(A) tail (24 nts) to the 3′UTR permits the specific binding of the poly(A) binding protein (PABP) present in HeLa cell extracts, as well as the recombinant PABP. Since La, PTB, and PABP are important trans-acting factors required for viral translation and replication, these RNA–protein interactions may play a role in NV replication or translation.
has issue date	2003-11-21(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2003.10.066
bibo:pmid	14623338
has license	els-covid
sha1sum (hex)	003f719a05b7a35ea4b778ded17cae230f5a0343
schema:url	https://doi.org/10.1016/j.bbrc.2003.10.066
resource representing a document's title	La, PTB, and PAB proteins bind to the 3′ untranslated region of Norwalk virus genomic RNA
has PubMed Central identifier	PMC7111188
has PubMed identifier	14623338
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:003f719a05b7a35ea4b778ded17cae230f5a0343#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/003f719a05b7a35ea4b778ded17cae230f5a0343
is schema:about of	named entity 'stable' named entity 'factors' named entity 'translation' named entity 'human' named entity 'Use' named entity 'protein' named entity 'Since' named entity 'permits' named entity 'stem-loop' named entity 'binding' named entity 'Proteins' named entity 'addition' named entity 'mechanisms' named entity 'genomic' named entity 'PAB' named entity 'binding protein' named entity 'poly(A) tail' named entity 'PABP' named entity 'cis' named entity 'PABP' named entity 'Noroviruses' named entity 'untranslated region' named entity 'Norwalk virus' named entity 'proteins' named entity 'untranslated region' named entity 'UTR' named entity 'UTR' named entity 'PCR' named entity 'protein complex' named entity 'RNAs' named entity 'UTR' named entity 'non-structural proteins' named entity 'cis' named entity 'antibodies' named entity 'RNA replication' named entity 'kDa' named entity 'binding site' named entity 'molecule' named entity 'UTR' named entity 'UTR' named entity 'RNA-protein complexes' named entity 'molecular mass' named entity 'stemloop' named entity 'RNA viruses' named entity 'complex II' named entity 'penicillin' named entity 'PABP' named entity 'cis' named entity 'electrophoresis' named entity 'RNA replication' named entity 'poly(A) tail' named entity 'UTR' named entity 'heterologous' named entity 'autoradiography' named entity 'critical role' named entity 'poly(A) tail' named entity 'protein' named entity 'PABP' named entity 'homologous' named entity 'kDa' named entity 'RNAs' named entity 'trans' named entity 'viral RNA' named entity 'promoter sequence' named entity 'replication process' named entity 'RNA-protein complexes' named entity 'kDa' named entity 'ORF 1' named entity 'cross-linked' named entity 'kDa' named entity 'molecular masses' named entity 'electrophoresis' named entity 'immunoprecipitated' named entity 'primer' named entity 'RNA' named entity 'UV-induced'

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