About: Absence of surface expression of feline infectious peritonitis virus (FIPV) antigens on infected cells isolated from cats with FIP

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About: Absence of surface expression of feline infectious peritonitis virus (FIPV) antigens on infected cells isolated from cats with FIP Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Absence of surface expression of feline infectious peritonitis virus (FIPV) antigens on infected cells isolated from cats with FIP
Creator	Nauwynck, H Cornelissen, E Dewerchin, H Hamme, E
Source	Elsevier; Medline; PMC
abstract	Feline infectious peritonitis virus (FIPV) positive cells are present in pyogranulomas and exudates from cats with FIP. These cells belong mainly to the monocyte/macrophage lineage. How these cells survive in immune cats is not known. In this study, FIPV positive cells were isolated from pyogranulomas and exudates of 12 naturally FIPV-infected cats and the presence of two immunologic targets, viral antigens and MHC I, on their surface was determined. The majority of the infected cells were confirmed to be cells from the monocyte/macrophage lineage. No surface expression of viral antigens was detected on FIPV positive cells. MHC I molecules were present on all the FIPV positive cells. After cultivation of the isolated infected cells, 52 ± 10% of the infected cells re-expressed viral antigens on the plasma membrane. In conclusion, it can be stated that in FIP cats, FIPV replicates in cells of the monocyte/macrophage lineage without carrying viral antigens in their plasma membrane, which could allow them to escape from antibody-dependent cell lysis.
has issue date	2007-03-31(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2006.11.026
bibo:pmid	17188823
has license	no-cc
sha1sum (hex)	0001418189999fea7f7cbe3e82703d71c85a6fe5
schema:url	https://doi.org/10.1016/j.vetmic.2006.11.026
resource representing a document's title	Absence of surface expression of feline infectious peritonitis virus (FIPV) antigens on infected cells isolated from cats with FIP
has PubMed Central identifier	PMC7127496
has PubMed identifier	17188823
schema:publication	Vet Microbiol
resource representing a document's body	covid:0001418189999fea7f7cbe3e82703d71c85a6fe5#body_text
is schema:about of	named entity 'molecules' named entity 'The majority' named entity 'expression' named entity 'viral antigens' named entity 'infected' named entity 'STUDY' named entity 'CATS' named entity 'CELLS' named entity 'MOLECULES' named entity 'MONOCYTE' named entity 'EXPRESSION' named entity 'HOW' named entity 'IMMUNE' named entity 'LINEAGE' named entity 'THESE' named entity 'ISOLATED' named entity 'EXPRESSION' named entity 'SURFACE' covid:arg/0001418189999fea7f7cbe3e82703d71c85a6fe5 named entity 'CATS' named entity 'FIP' named entity 'POSITIVE' named entity '10%' named entity 'MHC' named entity 'EXUDATES' named entity 'ANTIGENS' named entity 'PRESENT' named entity 'CONFIRMED' named entity 'DETERMINED' named entity 'THEIR' named entity 'SURVIVE' named entity 'ISOLATED' named entity 'NOT KNOWN' named entity 'DETECTED' named entity 'CELLS' named entity 'MAJORITY' named entity 'TARGETS' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'EXPRESSED' named entity 'FIP' named entity 'FELINE INFECTIOUS PERITONITIS VIRUS' named entity 'PLASMA MEMBRANE' named entity 'IMMUNOLOGIC' named entity 'INFECTED' named entity 'CULTIVATION' named entity 'SURFACE' named entity 'VIRAL ANTIGENS' named entity 'ABSENCE OF' named entity 'INFECTED' named entity 'infected' named entity 'cats' named entity 'virus' named entity 'macrophage' named entity 'cells' named entity 'cells' named entity 'viral antigens' named entity 'surface' named entity 'MHC I molecules' named entity 'macrophage' named entity 'FIPV' named entity 'monocyte' named entity 'FIPV' named entity 'herpesvirus' named entity 'viral replication' named entity 'infection' named entity 'FIPV' named entity 'plasma membrane' named entity 'FIPV' named entity 'coverslip' named entity 'FIP' named entity 'polyclonal antibodies' named entity 'viral antigens' named entity 'viral antigens' named entity 'viral proteins' named entity 'viral antigens' named entity 'glycerin' named entity 'antibody' named entity 'morphology'

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