About: G-Quadruplex DNA and RNA

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	G-Quadruplex DNA and RNA
Creator	Yang, Danzhou
Source	Medline; PMC
abstract	G-quadruplexes (G4s) have become one of the most exciting nucleic acid secondary structures. A noncanonical, four-stranded structure formed in guanine-rich DNA and RNA sequences, G-quadruplexes can readily form under physiologically relevant conditions and are globularly folded structures. DNA is widely recognized as a double-helical structure essential in genetic information storage. However, only ~3% of the human genome is expressed in protein; RNA and DNA may form noncanonical secondary structures that are functionally important. G-quadruplexes are one such example which have gained considerable attention for their formation and regulatory roles in biologically significant regions, such as human telomeres, oncogene-promoter regions, replication initiation sites, and 5′- and 3′-untranslated region (UTR) of mRNA. They are shown to be a regulatory motif in a number of critical cellular processes including gene transcription, translation, replication, and genomic stability. G-quadruplexes are also found in nonhuman genomes, particularly those of human pathogens. Therefore, G-quadruplexes have emerged as a new class of molecular targets for drug development. In addition, there is considerable interest in the use of G-quadruplexes for biomaterials, biosensors, and biocatalysts. The First International Meeting on Quadruplex DNA was held in 2007, and the G-quadruplex field has been growing dramatically over the last decade. The methods used to study G-quadruplexes have been essential to the rapid progress in our understanding of this exciting nucleic acid secondary structure.
has issue date	2019-08-23(xsd:dateTime)
bibo:doi	10.1007/978-1-4939-9666-7_1
bibo:pmid	31444741
has license	no-cc
sha1sum (hex)	ff1be979fed9e2b6048aed72fe3e5919e0306444
schema:url	https://doi.org/10.1007/978-1-4939-9666-7_1
resource representing a document's title	G-Quadruplex DNA and RNA
has PubMed Central identifier	PMC7121297
has PubMed identifier	31444741
schema:publication	G-Quadruplex Nucleic Acids
resource representing a document's body	covid:ff1be979fed9e2b6048aed72fe3e5919e0306444#body_text
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