About: Clinical features of community acquired adenovirus pneumonia during the 2011 community outbreak in Southern Taiwan: role of host immune response

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Clinical features of community acquired adenovirus pneumonia during the 2011 community outbreak in Southern Taiwan: role of host immune response Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical features of community acquired adenovirus pneumonia during the 2011 community outbreak in Southern Taiwan: role of host immune response
Creator	Liu, Ching-Chuan Wang, Shih-Min Ho, Tzong-Shiann Shen, Ching-Fen
Source	PMC
abstract	BACKGROUND: Human adenovirus 7 (HAdV-7) was responsible for a significant number of fatalities during the 2011 community outbreak in Taiwan. The mechanisms underlying the pathogenesis of severe adenovirus infections in non-immunocompromised individuals remain unclear. Adenovirus pneumonia was associated with pleural effusion in a number of patients from the 2011 outbreak suggesting that similar to bacterial pneumonia, patients diagnosed with adenovirus pneumonia who have pleural effusion are more severely and systemically infected, and may have a more protracted disease course. We hypothesized that the host immunological response determines the severity of adenoviral infection. METHODS: This retrospective case series study included patients diagnosed with severe lower respiratory tract infections at the National Cheng Kung University Hospital in southern Taiwan between December 2010 and October 2011. The main inclusion criteria were 1) presence of multifocal patchy infiltrates, lobar consolidation or reticular interstitial opacities in chest X-rays, and 2) presence of adenovirus isolated from respiratory specimens. All patients had adenovirus isolated from respiratory specimens, and were negative for other viruses. Pleural effusion was confirmed in all patients using chest echography. Clinical features and laboratory data were compared in patients with (n = 12) and without (n = 15) parapneumonic effusion. RESULTS: Presence of parapneumonic effusion was significantly associated with a longer febrile duration, more complicated clinical management, and a greater risk of extrapulmonary involvement, notably hepatitis. Patients without pleural effusion had significantly higher numbers of WBCs, platelets, and absolute segment cell counts (ASCs) compared to patients with pleural effusion (all p < 0.05). Patients without pleural effusion had significantly higher counts of CD4+, CD8+, and CD20+ T cells (all p < 0.05) compared to patients with pleural effusion. CONCLUSION: Our data indicated that presence of parapneumonic effusion in adenoviral pneumonia was associated with longer febrile duration, more complicated clinical management, a greater risk of hepatitis, and suppression of host cellular immunity. Further prospective, large-scale studies are needed to validate our results.
has issue date	2017-03-07(xsd:dateTime)
bibo:doi	10.1186/s12879-017-2272-5
bibo:pmid	28270104
has license	cc-by
sha1sum (hex)	fd6990c1480a98b0a0951ae0915a4759f1f94cdd
schema:url	https://doi.org/10.1186/s12879-017-2272-5
resource representing a document's title	Clinical features of community acquired adenovirus pneumonia during the 2011 community outbreak in Southern Taiwan: role of host immune response
has PubMed Central identifier	PMC5341368
has PubMed identifier	28270104
schema:publication	BMC Infect Dis
resource representing a document's body	covid:fd6990c1480a98b0a0951ae0915a4759f1f94cdd#body_text
is schema:about of	named entity 'adenovirus' named entity 'higher' named entity 'segment' named entity 'febrile' named entity 'numbers' named entity 'Clinical' named entity '2011' named entity 'risk' named entity 'infection' named entity 'greater' named entity 'presence' named entity 'compared' named entity 'pleural effusion' named entity 'pneumonia' named entity 'RISK OF' named entity 'INCLUDED' named entity '2011' named entity 'ADENOVIRUS' named entity 'NEGATIVE' named entity 'CLINICAL FEATURES' named entity 'ABSOLUTE' named entity 'MULTIFOCAL' named entity 'ISOLATED' named entity 'SUPPRESSION' named entity 'prospective' named entity 'opacities' named entity 'bacterial pneumonia' named entity 'echography' named entity 'inclusion' named entity 'Patients' named entity 'Methods' named entity 'Presence' named entity 'compared' named entity 'infections' named entity 'compared' named entity 'patients' named entity 'Results' named entity 'Taiwan' named entity 'higher' named entity 'validate' named entity 'CD8+' named entity 'Patients' named entity 'WBCs' named entity 'parapneumonic effusion' named entity 'pleural effusion' named entity 'lower respiratory tract infections' named entity 'immunological response' named entity 'adenovirus' named entity 'parapneumonic effusion' named entity 'febrile' named entity 'hepatitis' named entity 'National Cheng Kung University Hospital' named entity 'Adenovirus' named entity 'pleural effusion' named entity 'Taiwan' named entity 'bacterial pneumonia' named entity 'pneumonia' named entity 'pneumonia' named entity 'Stockport' named entity 'Mann-Whitney U test' named entity 'adenoviral' named entity 'normal distribution' named entity 'antigen test' named entity 'antigen test' named entity 'fever' named entity 'CD4+' named entity 'fatality rate' named entity '2, 3' named entity 'CDC' named entity 'adenovirus infection' named entity 'pharyngitis' named entity 'IL-6' named entity 'pediatric residents' named entity 'depression' named entity 'Taiwan' named entity 'CD4+ cells' named entity 'sample size' named entity 'parapneumonic effusion'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software