About: The Underlying Mechanism of 3-Hydroxyphthalic Anhydride-Modified Bovine Beta-Lactoglobulin to Block Human Papillomavirus Entry Into the Host Cell

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Underlying Mechanism of 3-Hydroxyphthalic Anhydride-Modified Bovine Beta-Lactoglobulin to Block Human Papillomavirus Entry Into the Host Cell Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Underlying Mechanism of 3-Hydroxyphthalic Anhydride-Modified Bovine Beta-Lactoglobulin to Block Human Papillomavirus Entry Into the Host Cell
Creator	Jiang, Shibo Zhu, Yun Rong, Lijun Wang, Qian Hua, Chen Si, Lulu Sui, Long Wu, Congquan Kim, Young Cn, Long Sui, Xiang, Yang
Source	Medline; PMC
abstract	We have previously demonstrated that 3-hydroxyphthalic anhydride (3HP)-modified bovine beta-lactoglobulin (3HP-β-LG) is highly effective in inhibiting entry of pseudovirus (PsV) of high- and low-risk human papillomavirus (HPV) into the target cell. Intravaginally applied 3HP-β-LG-containing vaginal gel could significantly inhibit HPV infection and reduce viral load in the cervical region. However, we still do not understand the underlying molecular mechanism by which 3HP-β-LG is able to inhibit HPV infection. Here, though, we showed that 3HP-β-LG did not inactivate HPV PsV, but rather blocked entry of HPV PsV into the target cell via its interaction with virus, not cell. It bound to the positively charged region in the HPV L1 protein, suggesting that 3HP-β-LG binds to HPV L1 protein through the interaction between the negatively charged region in 3HP-β-LG and the positively charged region in HPV L1 protein, thus competitively blocking the binding of HPV to the receptor on the basement membrane in vaginal mucosa. Although 3HP-modified chicken ovalbumin (3HP-OVA) also carries high net negative charges, it exhibited no anti-HPV activity, suggesting that the interaction between 3HP-modified protein and HPV L1 protein relies on both electrostatic and matchable conformation of the binding sites in both proteins. When topically applied, 3HP-β-LG did not enter the host cell or blood circulation. These findings suggest that 3HP-β-LG targets HPV L1 protein and blocks HPV entry into the host cell, thus being safe and effective for topical application in the treatment of HPV infection.
has issue date	2019-09-26(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.02188
bibo:pmid	31611852
has license	cc-by
sha1sum (hex)	fccc2cff358d6c08f512003b88bab9934e4ffa7a
schema:url	https://doi.org/10.3389/fmicb.2019.02188
resource representing a document's title	The Underlying Mechanism of 3-Hydroxyphthalic Anhydride-Modified Bovine Beta-Lactoglobulin to Block Human Papillomavirus Entry Into the Host Cell
has PubMed Central identifier	PMC6775479
has PubMed identifier	31611852
schema:publication	Front Microbiol
resource representing a document's body	covid:fccc2cff358d6c08f512003b88bab9934e4ffa7a#body_text
is schema:about of	named entity 'OVALBUMIN' named entity 'BUT' named entity 'REDUCE' named entity 'VIRAL LOAD' named entity 'PROTEIN ' named entity 'BINDING' named entity 'CELL' named entity 'ENTRY' named entity 'POSITIVELY CHARGED' named entity 'DO NOT' named entity 'TARGET CELL' named entity 'NET' named entity 'UNDERSTAND' named entity 'CHICKEN' named entity 'HIGHLY' named entity 'HPV' named entity 'HOST CELL' named entity 'CHARGES' named entity 'ITS' named entity 'HPV L1' named entity 'MOLECULAR MECHANISM' named entity 'ACTIVITY' named entity 'SUGGEST' named entity 'PROTEINS' named entity 'MODIFIED' named entity 'inhibit' named entity 'targets' named entity 'HPV' named entity 'molecular' named entity 'human papillomavirus' named entity 'cell' named entity 'Here' named entity 'protein' named entity 'carries' named entity 'chicken' named entity 'HOST CELL' covid:arg/fccc2cff358d6c08f512003b88bab9934e4ffa7a named entity 'APPLIED' named entity 'ENTER' named entity 'FINDINGS' named entity 'OVA' named entity 'THESE' named entity 'HPV INFECTION' named entity 'CONTAINING' named entity 'CERVICAL REGION' named entity 'BETA-LACTOGLOBULIN' named entity 'BASEMENT MEMBRANE' named entity 'VIRUS' named entity '3-HYDROXYPHTHALIC ANHYDRIDE' named entity 'BLOOD CIRCULATION' named entity 'RATHER' named entity 'RECEPTOR' named entity 'UNDERLYING' named entity 'ENTRY' named entity 'HUMAN PAPILLOMAVIRUS ' named entity '3-HYDROXYPHTHALIC ANHYDRIDE' named entity 'MECHANISM' named entity 'BLOCK' named entity 'INTERACTION' named entity 'PSV' named entity 'DID' named entity 'BLOCKED' named entity 'UNDERLYING' named entity 'REGION' named entity 'VAGINAL MUCOSA' named entity 'PREVIOUSLY' named entity 'EFFECTIVE' named entity 'ELECTROSTATIC' named entity 'INHIBITING' named entity 'VAGINAL GEL'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software