About: Membrane proteins with high N-glycosylation, high expression, and multiple interaction partners were preferred by mammalian viruses as receptors

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Membrane proteins with high N-glycosylation, high expression, and multiple interaction partners were preferred by mammalian viruses as receptors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Membrane proteins with high N-glycosylation, high expression, and multiple interaction partners were preferred by mammalian viruses as receptors
Creator	Zhang, Zheng Ge, Xingyi Jiang, Taijiao Peng, Yousong Zhu, Zhaozhong Wu, Aiping Tan, Zhongyang Zhu, Haizhen Cai, Zena Chen, Wenjun Xia, Zanxian Guo, Xinhong Xu, Beibei
Source	BioRxiv; MedRxiv
abstract	Receptor mediated entry is the first step for viral infection. However, the relationship between viruses and receptors is still obscure. Here, by manually curating a high-quality database of 268 pairs of mammalian virus-host receptor interaction, which included 128 unique viral species or sub-species and 119 virus receptors, we found the viral receptors were structurally and functionally diverse, yet they had several common features when compared to other cell membrane proteins: more protein domains, higher level of N-glycosylation, higher ratio of self-interaction and more interaction partners, and higher expression in most tissues of the host. Additionally, the receptors used by the same virus tended to co-evolve. Further correlation analysis between viral receptors and the tissue and host specificity of the virus shows that the virus receptor similarity was a significant predictor for mammalian virus cross-species. This work could deepen our understanding towards the viral receptor selection and help evaluate the risk of viral zoonotic diseases.
has issue date	2018-03-08(xsd:dateTime)
bibo:doi	10.1101/271171
has license	biorxiv
sha1sum (hex)	fc6812d62536afc0018f27069e17aba0f4063d09
schema:url	https://doi.org/10.1101/271171
resource representing a document's title	Membrane proteins with high N-glycosylation, high expression, and multiple interaction partners were preferred by mammalian viruses as receptors
schema:publication	bioRxiv
resource representing a document's body	covid:fc6812d62536afc0018f27069e17aba0f4063d09#body_text
is schema:about of	named entity 'features' named entity 'virus' named entity 'expression' named entity 'cell membrane' named entity 'similarity' named entity 'receptor' named entity 'host specificity' named entity 'viruses' named entity 'manually' named entity 'viral' named entity 'virus' named entity 'N-glycosylation' named entity 'This' named entity 'high' named entity 'virus' named entity 'viruses' named entity 'viral species' named entity 'high-quality' named entity 'N-glycosylation' named entity 'cardiomyopathy' named entity 'mammal species' named entity 'protein' named entity 'Arrhythmogenic' named entity 'cytoplasm' named entity 'sequence identity' named entity 'Focal adhesion' named entity 'KEGG' named entity 'C3d' named entity 'virus' named entity 'viruses' named entity 'virus' named entity 'mammal species' named entity 'Molecular Function' named entity 'glycoprotein' named entity 'protein sequences' named entity 'membrane proteins' named entity 'receptor protein' named entity 'complement C3b' named entity 'glycan' named entity 'phylogenetic tree' named entity 'mammal species' named entity 'respiratory tract' named entity 'statistical analysis' named entity 'Receiver Operating Characteristic' named entity 'host cell' named entity 'virus receptor' named entity 'homolog' named entity 'vesicle' named entity 'ligands' named entity 'genetic distance' named entity 'protein' named entity 'interaction partners' named entity 'Pfam' named entity 'housekeeping gene' named entity 'membrane protein' named entity 'co-evolution' named entity 'virus receptor' named entity 'mammal species' named entity 'low density lipoprotein receptor' named entity 'protein domain' named entity 'virus' named entity 'mammal species' named entity 'Biological Process' named entity 'mammal species' named entity 'cytokine' named entity 'viral protein' named entity 'interact' named entity 'receptor protein' named entity 'LDLR' named entity 'Glycans' named entity 'cytoplasmic' named entity 'mammal species'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software