About: Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity
Creator	Kim, Dong-Eun Hong, Chaesun Jiang, Yanxialei Choi, Won Lee, Jung Lee, Min Shin, Seung
Source	Medline; PMC
abstract	The ubiquitin-proteasome system (UPS) is the primary mechanism by which intracellular proteins, transcription factors, and many proteotoxic proteins with aggregation-prone structures are degraded. The UPS is reportedly downregulated in various neurodegenerative disorders, with increased proteasome activity shown to be beneficial in many related disease models. Proteasomes function under tonic inhibitory conditions, possibly via the ubiquitin chain-trimming function of USP14, a proteasome-associated deubiquitinating enzyme (DUB). We identified three specific RNA aptamers of USP14 (USP14-1, USP14-2, and USP14-3) that inhibited its deubiquitinating activity. The nucleotide sequences of these non-cytotoxic USP14 aptamers contained conserved GGAGG motifs, with G-rich regions upstream, and similar secondary structures. They efficiently elevated proteasomal activity, as determined by the increased degradation of small fluorogenic peptide substrates and physiological polyubiquitinated Sic1 proteins. Additionally, proteasomal degradation of tau proteins was facilitated in the presence of the UPS14 aptamers in vitro. Our results indicate that these novel inhibitory UPS14 aptamers can be used to enhance proteasome activity, and to facilitate the degradation of proteotoxic proteins, thereby protecting cells from various neurodegenerative stressors.
has issue date	2015-06-04(xsd:dateTime)
bibo:doi	10.1038/srep10757
bibo:pmid	26041011
has license	cc-by
sha1sum (hex)	fc5e4a2de7d202adad95ea3fe26625bdebe817cf
schema:url	https://doi.org/10.1038/srep10757
resource representing a document's title	Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity
has PubMed Central identifier	PMC4455164
has PubMed identifier	26041011
schema:publication	Sci Rep
resource representing a document's body	covid:fc5e4a2de7d202adad95ea3fe26625bdebe817cf#body_text
is schema:about of	named entity 'activity' named entity 'peptide' named entity 'mechanism' named entity 'UPS' named entity 'activity' named entity 'Degradation' named entity 'OPEN' covid:arg/fc5e4a2de7d202adad95ea3fe26625bdebe817cf named entity 'CONTAINED' named entity 'THESE' named entity 'ACTIVITY' named entity 'UBIQUITIN-PROTEASOME SYSTEM' named entity 'OUR' named entity 'PRESENCE OF' named entity 'PHYSIOLOGICAL' named entity 'POSSIBLY' named entity 'FUNCTION' named entity 'NOVEL' named entity 'RELATED' named entity 'CELLS' named entity 'SIMILAR' named entity 'SMALL' named entity 'NEURODEGENERATIVE DISORDERS' named entity 'CONDITIONS' named entity 'UBIQUITIN' named entity 'PROTECTING' named entity 'VARIOUS' named entity 'BENEFICIAL' named entity 'IDENTIFIED' named entity 'USP14' named entity 'PRIMARY' named entity 'SPECIFIC' named entity 'TAU PROTEINS' named entity 'PROTEINS' named entity 'RNA' named entity 'CONSERVED' named entity 'PROTEASOMES' named entity 'DISEASE MODELS' named entity 'USP14' named entity 'PROTEASOMAL DEGRADATION' named entity 'UPS' named entity 'PRONE' named entity 'DEGRADED' named entity 'NON-' named entity 'ACTIVITY' named entity 'PROTEASOME' named entity 'ENHANCED' named entity 'APTAMERS' named entity 'TAU' named entity 'PROTEASOME' named entity 'MOTIFS' named entity 'INCREASED' named entity 'STRUCTURES' named entity 'INTRACELLULAR' named entity 'DEGRADATION' named entity 'NUCLEOTIDE SEQUENCES' named entity 'G-RICH' named entity 'ITS' named entity 'STRESSORS' named entity 'TONIC' named entity 'ENHANCE' named entity 'REGIONS' named entity 'SECONDARY' named entity 'AGGREGATION' named entity 'RESULTS' named entity 'APTAMERS' named entity 'DEGRADATION' named entity 'UPSTREAM' named entity 'ELEVATED' named entity 'CYTOTOXIC' named entity 'DEUBIQUITINATING ENZYME' named entity 'TRANSCRIPTION FACTORS' named entity 'PEPTIDE' named entity 'ASSOCIATED' named entity 'IN VITRO'

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