About: Coronavirus nonstructural protein 1: common and distinct functions in the regulation of host and viral gene expression

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Coronavirus nonstructural protein 1: common and distinct functions in the regulation of host and viral gene expression
Creator	Makino, Shinji Narayanan, Krishna Lokugamage, Kumari Ramirez, Sydney
source	Elsevier; Medline; PMC
abstract	The recent emergence of two highly pathogenic human coronaviruses (CoVs), severe acute respiratory syndrome CoV and Middle East respiratory syndrome CoV, has ignited a strong interest in the identification of viral factors that determine the virulence and pathogenesis of CoVs. The nonstructural protein 1 (nsp1) of CoVs has attracted considerable attention in this regard as a potential virulence factor and a target for CoV vaccine development because of accumulating evidence that point to its role in the downregulation of host innate immune responses to CoV infection. Studies have revealed both functional conservation and mechanistic divergence among the nsp1 of different mammalian CoVs in perturbing host gene expression and antiviral responses. This review summarizes the current knowledge about the biological functions of CoV nsp1 that provides an insight into the novel strategies utilized by this viral protein to modulate host and viral gene expression during CoV infection.
has issue date	2015-04-01(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2014.11.019
bibo:pmid	25432065
has license	bronze-oa
sha1sum (hex)	fc4811b8013ca3d0f38ceb615a0330e8f001a9c1
schema:url	https://doi.org/10.1016/j.virusres.2014.11.019
resource representing a document's title	Coronavirus nonstructural protein 1: common and distinct functions in the regulation of host and viral gene expression
has PubMed Central identifier	PMC4444399
has PubMed identifier	25432065
schema:publication	Virus Research
resource representing a document's body	covid:fc4811b8013ca3d0f38ceb615a0330e8f001a9c1#body_text
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