About: The allele 4 of neck region liver-lymph node-specific ICAM-3-grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The allele 4 of neck region liver-lymph node-specific ICAM-3-grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The allele 4 of neck region liver-lymph node-specific ICAM-3-grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads
Creator	Alaoui, R Benjelloun, S Diepolder, H Ezzikouri, S Fakhir, F.-Z Khakoo, S Nadir, S Rebbani, K Thursz, M
Source	Elsevier; Medline; PMC
abstract	L-SIGN is a C-type lectin expressed on liver sinusoidal endothelial cells involved in the capture of hepatitis C virus and trans-infection of adjacent hepatocyte cells. The neck region of L-SIGN is highly polymorphic, with three to nine tandem repeats of 23 residues. This polymorphism is associated with a number of infectious diseases, but has not been explored in HCV. We therefore investigated the impact of L-SIGN neck region length variation on the outcome of HCV infection. We studied 322 subjects, 150 patients with persistent HCV infection, 63 individuals with spontaneous clearance and 109 healthy controls. In healthy subjects, we found a total of nine genotypes, with the 7/7 genotype being the most frequent (33%) followed by the 7/6 (22.9%) and the 7/5 (18.3%). The frequencies of the alleles were as follows: 7-LSIGN (56.4%), 6-LSIGN (20.2%), 5-L-SIGN (18.3%) and 4-L-SIGN (5%). The frequency of the 7/4 genotype was higher in spontaneous resolvers (14.3%) as compared with the persistent group (4%) (OR = 0.25, 95% CI = 0.07–0.82, p 0.022). In addition, we found that 4-L-SIGN was associated with spontaneous resolution of HCV infection (OR = 0.30, 95%CI, 0.12–0.74, p 0.005). Interestingly, patients with 4-L-SIGN had lower viral loads when compared with carriers of the 5 (p 0.001), 6 (p 0.021) and 7-alleles (p 0.048). The results indicate that neck region polymorphism of L-SIGN can influence the outcome of HCV infection and the four-tandem repeat is associated with clearance of HCV infection.
has issue date	2014-12-13(xsd:dateTime)
bibo:doi	10.1111/1469-0691.12403
bibo:pmid	24283933
has license	no-cc
sha1sum (hex)	fa6cd222803f9015c5325822ee864cc6bcdee151
schema:url	https://doi.org/10.1111/1469-0691.12403
resource representing a document's title	The allele 4 of neck region liver-lymph node-specific ICAM-3-grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads
has PubMed Central identifier	PMC7129123
has PubMed identifier	24283933
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:fa6cd222803f9015c5325822ee864cc6bcdee151#body_text
is schema:about of	named entity 'loads' named entity 'HCV' named entity 'frequent' named entity 'genotype' named entity 'repeat' named entity 'ADDITION' named entity 'INVOLVED' named entity '0.07' named entity 'GENOTYPE' named entity 'NECK REGION' named entity 'IMPACT' named entity 'LIVER' named entity 'THE NECK' named entity 'LECTIN' named entity 'HCV INFECTION' named entity 'HEALTHY' named entity 'CAPTURE' named entity '0.001' named entity '30%' named entity 'HEALTHY SUBJECTS' named entity 'CARRIERS' named entity 'INFECTIOUS DISEASES' named entity '7/4' named entity 'carriers' named entity 'persistent' named entity 'resolvers' named entity 'HCV' named entity 'group' named entity 'This' named entity 'neck' named entity '7/7' named entity 'neck' named entity 'hepatitis C virus' named entity 'tandem repeats' named entity 'length variation' named entity 'infection' named entity 'infection' named entity 'tandem repeat' named entity 'sinusoidal endothelial cells' named entity 'liver' named entity 'hepatitis C virus' named entity 'allele' named entity '95% CI' named entity 'genotype' named entity 'intracellular' named entity 'hepatic' named entity 'genotype' named entity 'IL28B' named entity 'lymph node' named entity '7/4' named entity 'Germany' named entity 'heterozygotes' named entity 'genotype frequencies' named entity 'viral entry' named entity 'HCV' named entity 'allele' named entity 'genotype' named entity 'polymorphisms' named entity 'RNA' named entity 'HCV' named entity 'calcium-dependent' named entity 'alleles' named entity 'Plasma' named entity 'world's population' named entity 'HCV' named entity 'HCV' named entity 'pathogen' named entity 'genotype frequencies' named entity 'HCV' named entity 'Pasteur Institute' named entity 'AST' named entity 'adhesion' named entity 'tandem repeats'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software