About: The effect of loss of regulation of minus-strand RNA synthesis on sindbis virus replication

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About: The effect of loss of regulation of minus-strand RNA synthesis on sindbis virus replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The effect of loss of regulation of minus-strand RNA synthesis on sindbis virus replication
Creator	Sawicki, Dorothea Sawicki' And, Stanley
Source	Elsevier; Medline; PMC
abstract	Abstract During the replication cycle of Sindbis virus minus-strand synthesis stops normally at the time that plus-strand synthesis reaches a maximum rate. We have isolated and characterized revertants of ts24, a member of the A complementation group of Sindbis HR mutants, that we had demonstrated previously to have a temperature-sensitive defect in the regulation of minus-strand synthesis. These revertants of ts24 replicated efficiently at 40° but nevertheless retained the temperature sensitive defect in the regulation of minus-strand synthesis: they continued to synthesize minus strands late in the replication cycle at 40° but not at 30° and in the presence or absence of protein synthesis. Although failure to regulate the synthesis of minus strands resulted in continuous minus-strand synthesis and in the accumulation of minus strands, the rate of plus-strand synthesis was not increased concertedly. Minus strands synthesized after the rate of plus-strand synthesis had become constant were demonstrated to be utilized as templates for 26 S mRNA synthesis. Thus, the change from an increasing to a constant rate of plus-strand synthesis during the alphavirus replication cycle cannot be governed solely by the number of minus strands that accumulate in infected cells. We present a model for the preferential utilization of minus strands as a mechanism for the cessation of minus-strand synthesis that occurs normally during alphavirus replication.
has issue date	1986-06-30(xsd:dateTime)
bibo:doi	10.1016/0042-6822(86)90054-1
bibo:pmid	3705466
has license	els-covid
sha1sum (hex)	fa5d0074495d60de05c6a95a182bbc299f2fb7d5
schema:url	https://doi.org/10.1016/0042-6822%2886%2990054-1
resource representing a document's title	The effect of loss of regulation of minus-strand RNA synthesis on sindbis virus replication
has PubMed Central identifier	PMC7131060
has PubMed identifier	3705466
schema:publication	Virology
resource representing a document's body	covid:fa5d0074495d60de05c6a95a182bbc299f2fb7d5#body_text
is schema:about of	named entity 'LOSS OF' named entity 'replication cycle' named entity 'minus-strand' named entity 'late' named entity 'isolated' named entity 'Virus' named entity 'SYNTHESIS' named entity 'DEFECT' named entity 'PRESENT' named entity 'INCREASED' named entity 'TIME' named entity 'TEMPLATES' named entity 'UTILIZATION' named entity 'EFFECT' named entity 'TEMPERATURE-SENSITIVE' named entity 'PROTEIN SYNTHESIS' named entity 'RATE' named entity 'MINUS' named entity 'THE CHANGE' named entity 'THESE' named entity '40%' named entity 'INFECTED' named entity '30%' named entity 'MEMBER OF' named entity 'HAVE' named entity 'ISOLATED' named entity 'LATE' named entity 'STRAND' named entity 'ACCUMULATION' named entity 'PRESENCE' named entity 'TS24' named entity 'ABSENCE OF' named entity 'MAXIMUM' named entity 'CELLS' named entity 'REGULATION' named entity 'REACHES' named entity 'CHARACTERIZED' covid:arg/fa5d0074495d60de05c6a95a182bbc299f2fb7d5 named entity 'MUTANTS' named entity 'MODEL' named entity 'RETAINED' named entity 'BUT' named entity 'TO REGULATE' named entity 'INCREASING' named entity 'VIRUS REPLICATION' named entity 'RNA SYNTHESIS' named entity 'REGULATION' named entity 'MINUS' named entity 'GROUP' named entity 'REPLICATION' named entity 'PREVIOUSLY' named entity 'MRNA SYNTHESIS' named entity 'CONSTANT' named entity 'CONTINUOUS' named entity 'CESSATION' named entity 'REPLICATED' named entity 'FAILURE' named entity 'COMPLEMENTATION' named entity 'CONTINUED' named entity 'ALPHAVIRUS' named entity 'NUMBER OF' named entity 'DEMONSTRATED' named entity 'SINDBIS VIRUS' named entity 'TEMPERATURE SENSITIVE' named entity 'REPLICATION CYCLE' named entity 'STOPS' named entity 'MECHANISM' named entity 'SINDBIS VIRUS' named entity 'STRAND' named entity 'model' named entity 'reaches' named entity 'virus' named entity 'synthesized' named entity 'replication cycle' named entity 'mRNA' named entity 'constant' named entity 'minus-strand' named entity 'number' named entity 'Replication' named entity 'alphavirus'

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