About: The tree shrew provides a useful alternative model for the study of influenza H1N1 virus

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About: The tree shrew provides a useful alternative model for the study of influenza H1N1 virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The tree shrew provides a useful alternative model for the study of influenza H1N1 virus
Creator	Zhong, Nan-Shan Yang, Zi-Feng Li, Run-Feng Wang, Yu-Tao Yang, Chun-Guang Zhao, Jin Liu, Rong Li, Ji-Qiang Zhao, Sui-Shan Zhu, Yu-Tong
Source	Medline; PMC
abstract	BACKGROUND: The influenza pandemics have resulted in significant morbidity and mortality worldwide. Animal models are useful in the study of influenza virus pathogenesis. Because of various limitations in current laboratory animal models, it is essential to develop new alternative animal models for influenza virus research aimed at understanding the viral and host factors that contribute to virus infection in human. METHOD: We investigated the replicative efficiency of influenza H1N1 virus (classic strain (Influenza A/PR/8/34), seasonal influenza isolate (A/Guangzhou/GIRD/02/09) and swine-origin human influenza virus (A/Guangzhou/GIRD/07/09)) at Day1,2,4,6 and 9 p.i. using TCID(50) and qPCR assay in tree shrew model. Body temperature was monitored in the morning and evening for 3 days before infection and for 14 days. Seroconversion was detected by determining the neutralizing antibody titers against the challenge viruses in the pre- and exposure serum samples collected before infection and at 14 days p.i., respectively. Lungs and tracheas of tree shews were collected at day 14 post p.i. for histopathological analysis. Lectinhistochemistry analysis was conducted to identify the distribution of SAα2,3 Gal and SAα2,6 Gal receptors in the lung and trachea. RESULTS: The infected tree shrew displayed mild or moderate systemic and respiratory symptoms and pathological changes in respiratory tracts. The human H1N1 influenza virus may replicate in the upper respiratory tract of tree shrews. Analysis of the receptors distribution in the respiratory tract of tree shrews by lectinhistochemistry showed that sialic acid (SA)α2,6-Gal receptors were widely distributed in the trachea and nasal mucosa, whereas (SA)α2,3-Gal receptor was the main receptor in the lung tissue. CONCLUSIONS: Based on these findings, tree shrew seemed to mimic well influenza virus infection in humans. We propose that tree shrews could be a useful alternative mammalian model to study pathogenesis of influenza H1N1 virus.
has issue date	2013-04-10(xsd:dateTime)
bibo:doi	10.1186/1743-422x-10-111
bibo:pmid	23575279
has license	cc-by
sha1sum (hex)	fa07cb83c9ec268f4be524c374659bc3584fca6f
schema:url	https://doi.org/10.1186/1743-422x-10-111
resource representing a document's title	The tree shrew provides a useful alternative model for the study of influenza H1N1 virus
has PubMed Central identifier	PMC3639867
has PubMed identifier	23575279
schema:publication	Virol J
resource representing a document's body	covid:fa07cb83c9ec268f4be524c374659bc3584fca6f#body_text
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