About: Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors

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About: Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors
Creator	Rao, Zihe Yan, Huimin Xiao, Gengfu Tien, Po Gao, George Zheng, Congyi Zhu, Jieqing Liu, Yueyong Xu, Yanhui Yuan, Fang Bell, John Cole, David
Source	Elsevier; Medline; PMC
abstract	Abstract Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is a newly identified member of Family Coronaviridae. Coronavirus envelope spike protein S is a class I viral fusion protein which is characterized by the existence of two heptad repeat regions (HR1 and HR2) (forming a complex called fusion core). Here we report that by using in vitro bio-engineering techniques, SARS-CoV HR1 and HR2 bind to each other and form a typical 6-helix bundle. The HR2, either as a synthetic peptide or as a GST-fusion polypeptide, is a potent inhibitor of virus entry. The results do show that SARS-CoV follows the general fusion mechanism of class I viruses and this lays the ground for identification of virus fusion/entry inhibitors for this devastating emerging virus.
has issue date	2004-06-18(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2004.04.141
bibo:pmid	15158473
has license	els-covid
sha1sum (hex)	f9f0b6eb74685972364b796a69bc0889d195707a
schema:url	https://doi.org/10.1016/j.bbrc.2004.04.141
resource representing a document's title	Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors
has PubMed Central identifier	PMC7111185
has PubMed identifier	15158473
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:f9f0b6eb74685972364b796a69bc0889d195707a#body_text
is schema:about of	named entity 'class I' named entity 'fusion' named entity 'inhibitor' named entity 'spike' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'REGIONS' named entity 'VIRAL' named entity 'TYPICAL' named entity 'GENERAL' named entity 'IDENTIFIED' named entity 'IS A' named entity 'PROTEIN S' named entity 'HERE' named entity 'REPEAT' named entity 'RESULTS' named entity 'CORONAVIRUS' named entity 'PROTEIN ' named entity 'EITHER' named entity 'FUSION PROTEIN' named entity 'FOLLOWS' named entity 'MEMBER OF' named entity 'A CLASS' named entity 'CLASS I' named entity 'SARS-COV' named entity 'BIND' named entity 'ENGINEERING' named entity 'FAMILY CORONAVIRIDAE' named entity 'IN VITRO' named entity 'ENVELOPE' named entity 'MECHANISM' named entity 'FORM' named entity 'SYNTHETIC PEPTIDE' named entity 'VIRUSES' named entity 'BUNDLE' named entity 'GROUND' named entity 'SPIKE PROTEIN' named entity 'IDENTIFICATION' named entity 'HR1' named entity 'USING' named entity 'HELIX' named entity 'LAYS' named entity 'FUSION' named entity 'VIRUS ENTRY' named entity 'NEWLY' named entity 'TECHNIQUES' named entity 'HR2' named entity 'COMPLEX' named entity 'REPORT' named entity 'CHARACTERIZED' named entity 'POLYPEPTIDE' named entity 'VIRUS' named entity 'INHIBITOR' named entity 'CORE' covid:arg/f9f0b6eb74685972364b796a69bc0889d195707a named entity 'envelope' named entity 'virus' named entity 'fusion protein' named entity 'signal sequence' named entity 'GST' named entity 'coiled coil' named entity 'Novagen' named entity 'GST' named entity 'polypeptides' named entity 'IPTG' named entity 'viral' named entity 'HR1' named entity 'spike protein' named entity 'SARS-CoV' named entity 'peptide' named entity 'entry inhibitors'

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