About: Induction of insert-specific immune response in mice by hamster polyomavirus VP1 derived virus-like particles carrying LCMV GP33 CTL epitope

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About: Induction of insert-specific immune response in mice by hamster polyomavirus VP1 derived virus-like particles carrying LCMV GP33 CTL epitope Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Induction of insert-specific immune response in mice by hamster polyomavirus VP1 derived virus-like particles carrying LCMV GP33 CTL epitope
Creator	Blohm, Ulrike Gedvilaite, Alma Mazeike, Egle
Source	Elsevier; Medline; PMC
abstract	Abstract Hamster polyomavirus (HaPyV) major capsid protein VP1 based chimeric virus-like particles (VLPs) carrying model GP33 CTL epitope derived from Lymphocytic choriomeningitis virus (LCMV) were generated in yeast and examined for their capability to induce CTL response in mice. Chimeric VP1-GP33 VLPs were effectively processed in antigen presenting cells in vitro and in vivo and induced antigen-specific CD8+ T cell proliferation. Mice immunized only once with VP1-GP33 VLPs without adjuvant developed an effective GP33-specific memory T cell response: 70% were fully and 30% partially protected from LCMV infection. Moreover, aggressive growth of tumors expressing GP33 was significantly delayed in these mice in vivo. Therefore, HaPyV VP1-derived VLP harboring CTL epitopes are attractive vaccine candidates for the induction of insert-specific CTL immune response.
has issue date	2012-01-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2011.08.003
bibo:pmid	21864590
has license	els-covid
sha1sum (hex)	f9c1e38f9dc4fdbcd4aa6ebf7bf7022053215762
schema:url	https://doi.org/10.1016/j.virusres.2011.08.003
resource representing a document's title	Induction of insert-specific immune response in mice by hamster polyomavirus VP1 derived virus-like particles carrying LCMV GP33 CTL epitope
has PubMed Central identifier	PMC7114473
has PubMed identifier	21864590
schema:publication	Virus Research
resource representing a document's body	covid:f9c1e38f9dc4fdbcd4aa6ebf7bf7022053215762#body_text
is schema:about of	named entity 'AGGRESSIVE' named entity 'T CELL RESPONSE' named entity 'ATTRACTIVE' named entity 'PROCESSED' named entity 'GENERATED' named entity 'IMMUNE RESPONSE' named entity 'IN VIVO' named entity 'YEAST' named entity 'PARTIALLY' named entity 'MEMORY T CELL' named entity 'EXAMINED FOR' named entity 'HAMSTER POLYOMAVIRUS' named entity 'T CELL PROLIFERATION' named entity 'MICE' named entity 'LCMV' named entity 'SPECIFIC IMMUNE RESPONSE' covid:arg/f9c1e38f9dc4fdbcd4aa6ebf7bf7022053215762 named entity 'INSERT' named entity 'CTL' named entity 'INDUCTION' named entity 'VLP' named entity 'ANTIGEN PRESENTING CELLS' named entity 'CHIMERIC VIRUS' named entity 'INDUCED' named entity 'VIRUS-LIKE PARTICLES' named entity 'VP1' named entity 'EPITOPE' named entity 'DERIVED' named entity 'GP33' named entity 'INSERT' named entity 'GROWTH' named entity 'DERIVED' named entity 'VP1' named entity 'ADJUVANT' named entity 'ANTIGEN' named entity 'INFECTION' named entity 'LYMPHOCYTIC CHORIOMENINGITIS VIRUS' named entity 'EPITOPES' named entity 'DELAYED' named entity 'FULLY' named entity 'CD8' named entity 'CTL' named entity 'VLPS' named entity 'INDUCE' named entity 'SPECIFIC' named entity 'LCMV' named entity 'HARBORING' named entity 'BASED' named entity 'PROTEIN ' named entity 'VIRUS-LIKE PARTICLES' named entity 'THEIR' named entity 'MODEL' named entity 'RESPONSE' named entity 'EPITOPE' named entity 'EFFECTIVE' named entity 'INDUCTION' named entity 'MICE' named entity 'HAMSTER POLYOMAVIRUS' named entity '30%' named entity 'CARRYING' named entity '70%' named entity 'MAJOR CAPSID PROTEIN' named entity 'IN VITRO' named entity 'CHIMERIC' named entity 'TUMORS' named entity 'CAPABILITY' named entity 'CARRYING' named entity 'VACCINE' named entity 'GP33' named entity 'IMMUNIZED' named entity 'THESE' named entity 'antigen' named entity 'memory T cell' named entity 'major capsid protein VP1' named entity 'Mice' named entity 'VLPs' named entity 'CTL response' named entity 'antigen presenting cells' named entity 'mice'

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