About: Possible roles of monocytes/macrophages in response to elephant endotheliotropic herpesvirus (EEHV) infections in Asian elephants (Elephas maximus)

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Possible roles of monocytes/macrophages in response to elephant endotheliotropic herpesvirus (EEHV) infections in Asian elephants (Elephas maximus) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Possible roles of monocytes/macrophages in response to elephant endotheliotropic herpesvirus (EEHV) infections in Asian elephants (Elephas maximus)
Creator	Boonprasert, Khajohnpat Chuammitri, Phongsakorn Guntawang, Thunyamas Janyamethakul, Thittaya Khammesri, Siripat Kochagul, Varankpicha Langkaphin, Warangkhana Photichai, Kornravee Punyapornwithaya, Veerasak Sittisak, Tidaratt Srivorakul, Saralee Dong, Hang Farm, Patara Mai, Chiang Pringproa Id, Kidsadagon Thitaram Id, Chatchote
Source	PMC
abstract	Elephant endotheliotropic herpesvirus-hemorrhagic disease (EEHV-HD) is the primary cause of acute, highly fatal, hemorrhagic diseases in young Asian elephants. Although monocytopenia is frequently observed in EEHV-HD cases, the role monocytes play in EEHV-disease pathogenesis is unknown. This study seeks to explain the responses of monocytes/macrophages in the pathogenesis of EEHV-HD. Samples of blood, frozen tissues, and formalin-fixed, paraffin-embedded (FFPE) tissues from EEHV1A-HD, EEHV4-HD, co-infected EEHV1A and 4-HD, and EEHV-negative calves were analyzed. Peripheral blood mononuclear cells (PBMCs) from the persistent EEHV4-infected and EEHV-negative calves were also studied. The results showed increased infiltration of Iba-1-positive macrophages in the inflamed tissues of the internal organs of elephant calves with EEHV-HD. In addition, cellular apoptosis also increased in the tissues of elephants with EEHV-HD, especially in the PBMCs, compared to the EEHV-negative control. In the PBMCs of persistent EEHV4-infected elephants, cytokine mRNA expression was high, particularly up-regulation of TNF-α and IFN-γ. Moreover, viral particles were observed in the cytoplasm of the persistent EEHV4-infected elephant monocytes. Our study demonstrated for the first time that apoptosis of the PBMCs increased in cases of EEHV-HD. Furthermore, this study showed that monocytes may serve as a vehicle for viral dissemination during EEHV infection in Asian elephants.
has issue date	2019-09-06(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0222158
bibo:pmid	31491031
has license	cc-by
sha1sum (hex)	f80a73f77c3831a921a232122099f8aa5798dfd2
schema:url	https://doi.org/10.1371/journal.pone.0222158
resource representing a document's title	Possible roles of monocytes/macrophages in response to elephant endotheliotropic herpesvirus (EEHV) infections in Asian elephants (Elephas maximus)
has PubMed Central identifier	PMC6730851
has PubMed identifier	31491031
schema:publication	PLoS One
resource representing a document's body	covid:f80a73f77c3831a921a232122099f8aa5798dfd2#body_text
is schema:about of	named entity 'ASIAN' named entity 'observed' named entity 'serve' named entity 'blood' named entity 'study' named entity 'persistent' named entity 'Although' named entity 'elephant' named entity 'MAXIMUS' named entity 'ELEPHANT' named entity 'HEMORRHAGIC DISEASE' named entity 'RESPONSES' named entity 'SAMPLES' named entity 'ASIAN' named entity 'OBSERVED' named entity 'ROLE' named entity 'POSITIVE' named entity 'DISSEMINATION' named entity 'FROZEN' named entity 'INTERNAL' named entity 'FIXED' named entity 'HERPESVIRUS' named entity 'APOPTOSIS' named entity 'MRNA EXPRESSION' named entity 'PARAFFIN-EMBEDDED' named entity 'CYTOPLASM' named entity 'HIGHLY' named entity 'HIGH' named entity 'VIRAL PARTICLES' named entity 'ACUTE' named entity 'CASES' named entity 'MONOCYTOPENIA' named entity 'CELLULAR' named entity 'ORGANS' named entity 'ELEPHANTS' named entity 'PATHOGENESIS' named entity 'TO EXPLAIN' named entity 'INFLAMED' named entity 'UNKNOWN' named entity 'TISSUES' named entity 'INFILTRATION' named entity 'MONOCYTES' named entity 'IFN' named entity 'RESULTS' named entity 'POSSIBLE' named entity 'DISEASE' named entity 'STUDY' named entity 'FREQUENTLY' named entity 'FORMALIN' named entity 'PERSISTENT' named entity 'TIME' named entity 'RESPONSE TO' named entity 'CYTOKINE ' named entity 'UP-REGULATION' named entity 'BLOOD' named entity 'YOUNG' named entity 'CALVES' named entity 'ELEPHANTS' named entity 'HERPESVIRUS' named entity 'PBMCS' named entity 'INFECTIONS' named entity 'ROLES' named entity 'INCREASED' named entity 'NEGATIVE' named entity 'OUR' named entity 'PLAY'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software