About: Long-Term Results After Adult Ex Situ Split Liver Transplantation Since Its Introduction in 1987

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Long-Term Results After Adult Ex Situ Split Liver Transplantation Since Its Introduction in 1987
Creator	Kaltenborn, Alexander Kousoulas, Lampros Lehner, Frank Schrem, Harald Jü Rgen Klempnauer, • Lankisch, Oliver Lea, • Moritz, • Tim, Kleine
Source	PMC
abstract	BACKGROUND: Split liver transplantation is still discussed controversially. Utilization of split liver grafts has been declining since a change of allocation rules for the second graft abolished incentives for German centres to perform ex situ splits. We therefore analysed our long-term experiences with the first ex situ split liver transplant series worldwide. METHODS: A total of 131 consecutive adult ex situ split liver transplants (01.12.1987–31.12.2010) were analysed retrospectively. RESULTS: Thirty-day mortality rates and 1- and 3-year patient survival rates were 13, 76.3, and 66.4 %, respectively. One- and three-year graft survival rates were 63.4 and 54.2 %, respectively. The observed 10-year survival rate was 40.6 %. Continuous improvement of survival from era 1 to 3 was observed (each era: 8 years), indicating a learning curve over 24 years of experience. Patient and graft survival were not influenced by different combinations of transplanted segments or types of biliary reconstruction (p > 0.05; Cox regression). Patients transplanted for primary sclerosing cholangitis had better survival (p = 0.021; log-rank), whereas all other indications including acute liver failure (13.6 %), acute and chronic graft failure (9.1 %) had no significant influence on survival (p > 0.05; log-rank). Biliary complications (27.4 %) had no significant influence on patient or graft survival (p > 0.05; log-rank). Hepatic artery thrombosis (13.2 %) had a significant influence on graft survival but not on patient survival (p = 0.002, >0.05, respectively; log-rank). CONCLUSIONS: Split liver transplantation can be used safely and appears to be an underutilized resource that may benefit from liberal allocation of the second graft.
has issue date	2014-01-11(xsd:dateTime)
bibo:doi	10.1007/s00268-013-2444-4
bibo:pmid	24414197
has license	no-cc
sha1sum (hex)	f7d0251d396eace3084952c878eb0a1337d9a1df
schema:url	https://doi.org/10.1007/s00268-013-2444-4
resource representing a document's title	Long-Term Results After Adult Ex Situ Split Liver Transplantation Since Its Introduction in 1987
has PubMed Central identifier	PMC7102172
has PubMed identifier	24414197
schema:publication	World J Surg
resource representing a document's body	covid:f7d0251d396eace3084952c878eb0a1337d9a1df#body_text
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