About: Effects of environmental factors on severity and mortality of COVID-19

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About: Effects of environmental factors on severity and mortality of COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effects of environmental factors on severity and mortality of COVID-19
Creator	Cai, Ting Vapalahti, Olli Barrios, Clara Pascual, Julio Kantele, Anu Markotić, Alemka Horcajada, Juan Menni, Cristina Spector, Tim Steves, Claire Valdes, Ana Epis, Oscar Lauc, Gordan Lorini, Luca Murray, Benjamin Ourselin, Sebastien Primorac, Dragan Sudre, Carole Ughi, Nicola Wierzba, Waldemar Peršec, Jasminka Castells, Xavier Aithal, Guruprasad Allegri, Massimo Bettinelli, Silvia Posso, Margarita Postula, Marek Brachmann, Johannes Bugada, Dario Sajantila, Antti Giannattasio, Cristina Gudelj, Ivan Kajova, Mikael Kalogjera, Livije Kifer, Domagoj Krol, Zbigniew Lukšić, Ivica Maloberti, Alessandro Ollivere, Benjamin Ollivere, Luke Rossetti, Claudio Ugrina, Ivo Villar-Garcia, Judit Vučković, Frano Wojtowicz, Rafal Yan, Huadong Zaczynski, Artur Zycinska, Katarina
Source	MedRxiv
abstract	Background Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2 this still needs to be documented. Methods We examined the disease progression of COVID-19 in 6,911 patients admitted to hospitals in Europe and China. In addition, we evaluated progress of disease symptoms in 37,187 individuals reporting symptoms into the COVID Symptom Study application. Findings Meta-analysis of the mortality risk in eight European hospitals estimated odds ratios per one day increase in the admission date to be 0.981 (0.973-0.988, p<0.001) and per increase in ambient temperature of one degree Celsius to be 0.854 (0.773-0.944, p=0.007). Statistically significant decreases of comparable magnitude in median hospital stay, probability of transfer to Intensive Care Unit and need for mechanical ventilation were also observed in most, but not all hospitals. The analysis of individually reported symptoms of 37,187 individuals in the UK also showed the decrease in symptom duration and disease severity with time. Interpretation Severity of COVID-19 in Europe decreased significantly between March and May and the seasonality of COVID-19 is the most likely explanation. Mucosal barrier and mucociliary clearance can significantly decrease viral load and disease progression, and their inactivation by low relative humidity of indoor air might significantly contribute to severity of the disease.
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.1101/2020.07.11.20147157
has license	medrxiv
sha1sum (hex)	f7ac65bfb2d1ef4f9a736a8b8df439d8d231ff68
schema:url	https://doi.org/10.1101/2020.07.11.20147157
resource representing a document's title	Effects of environmental factors on severity and mortality of COVID-19
resource representing a document's body	covid:f7ac65bfb2d1ef4f9a736a8b8df439d8d231ff68#body_text
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