About: An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines
Creator	Igartua, Manoli Salvador, Aiala Luis Pedraz, José Maria Hernández, Rosa
source	Medline; PMC
abstract	The development of synthetic peptide-based vaccines has many advantages in comparison with vaccines based on live attenuated organisms, inactivated or killed organism, or toxins. Peptide-based vaccines cannot revert to a virulent form, allow a better conservation, and are produced more easily and safely. However, they generate a weaker immune response than other vaccines, and the inclusion of adjuvants and/or the use of vaccine delivery systems is almost always needed. Among vaccine delivery systems, micro- and nanoparticulated ones are attractive, because their particulate nature can increase cross-presentation of the peptide. In addition, they can be passively or actively targeted to antigen presenting cells. Furthermore, particulate adjuvants are able to directly activate innate immune system in vivo. Here, we summarize micro- and nanoparticulated vaccine delivery systems used in the field of synthetic peptide-based vaccines as well as strategies to increase their immunogenicity.
has issue date	2011-06-15(xsd:dateTime)
bibo:doi	10.1155/2011/181646
bibo:pmid	21773041
has license	cc-by
sha1sum (hex)	f7185938312bfa794681998fe0bff4e2697c053d
schema:url	https://doi.org/10.1155/2011/181646
resource representing a document's title	An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines
has PubMed Central identifier	PMC3134826
has PubMed identifier	21773041
schema:publication	J Drug Deliv
resource representing a document's body	covid:f7185938312bfa794681998fe0bff4e2697c053d#body_text
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