About: Proteomic Analysis of the Vitreous following Experimental Retinal Detachment in Rabbits

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About: Proteomic Analysis of the Vitreous following Experimental Retinal Detachment in Rabbits Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Proteomic Analysis of the Vitreous following Experimental Retinal Detachment in Rabbits
Creator	Heegaard, Steffen Honoré, Bent Mandal, Nakul Vorum, Henrik Fisher, Steven Lewis, Geoffrey Prause, Jan La Cour, Morten
Source	PMC
abstract	Purpose. The pathogenesis of rhegmatogenous retinal detachment (RRD) remains incompletely understood, with no clinically effective treatment for potentially severe complications such as photoreceptor cell death and proliferative vitreoretinopathy. Here we investigate the protein profile of the vitreous following experimental retinal detachment using a comparative proteomic based approach. Materials and Methods. Retinal detachment was created in the right eyes of six New Zealand red pigmented rabbits. Sham surgery was undertaken in five other rabbits that were used as controls. After seven days the eyes were enucleated and the vitreous was removed. The vitreous samples were evaluated with two-dimensional polyacrylamide gel electrophoresis and the differentially expressed proteins were identified with tandem mass spectrometry. Results. Ten protein spots were found to be at least twofold differentially expressed when comparing the vitreous samples of the sham and retinal detachment surgery groups. Protein spots that were upregulated in the vitreous following retinal detachment were identified as albumin fragments, and those downregulated were found to be peroxiredoxin 2, collagen-Iα1 fragment, and α-1-antiproteinase F. Conclusions. Proteomic investigation of the rabbit vitreous has identified a set of proteins that help further our understanding of the pathogenesis of rhegmatogenous retinal detachment and its complications.
has issue date	2015-11-18(xsd:dateTime)
bibo:doi	10.1155/2015/583040
bibo:pmid	26664739
has license	cc-by
sha1sum (hex)	f6e4ddea2e155bf319fedff2b6111ba9ee863f1e
schema:url	https://doi.org/10.1155/2015/583040
resource representing a document's title	Proteomic Analysis of the Vitreous following Experimental Retinal Detachment in Rabbits
has PubMed Central identifier	PMC4667062
has PubMed identifier	26664739
schema:publication	J Ophthalmol
resource representing a document's body	covid:f6e4ddea2e155bf319fedff2b6111ba9ee863f1e#body_text
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