About: In vitro human fecal microbial metabolism of Forsythoside A and biological activities of its metabolites

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About: In vitro human fecal microbial metabolism of Forsythoside A and biological activities of its metabolites Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vitro human fecal microbial metabolism of Forsythoside A and biological activities of its metabolites
Creator	Chen, Daofeng Li, Xiaobo Peng, Ying Wang, Mengyue Xing, Shihua
Source	Elsevier; Medline; PMC
abstract	Abstract The present study aimed to investigate the metabolism of Forsythoside A (FTA) by human fecal bacteria to clarify the relationship between its intestinal metabolism and its pharmacological activities. FTA was incubated with human fecal microflora in vitro to investigate its metabolic process, and highly sensitive and specific ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC–Q-TOF/MS) was performed using MetaboLynx™ software for metabolite analysis. Caffeic acid (CA) and hydroxytyrosol (HT) were obtained by hydrolysis of FTA, and CA was further hydrogenated to form 3,4-dihydroxybenzenepropionic acid (DCA). The anticomplementary, antimicrobial and antiendotoxin activities of FTA and its metabolites by human fecal microflora were evaluated in vitro with a hemolysis assay, the agar disc-diffusion method, the MIC value and the gel clot LAL assay, respectively. The metabolites showed higher biological activity than FTA, especially HT and DCA. Orally administered FTA may be metabolized to HT and DCA, and the pharmacological effects of FTA may be dependent on intestinal bacterial metabolism.
has issue date	2014-12-31(xsd:dateTime)
bibo:doi	10.1016/j.fitote.2014.09.018
bibo:pmid	25281775
has license	els-covid
sha1sum (hex)	f6d5f516742718fb9229c7bb4abde7bc290c08c5
schema:url	https://doi.org/10.1016/j.fitote.2014.09.018
resource representing a document's title	In vitro human fecal microbial metabolism of Forsythoside A and biological activities of its metabolites
has PubMed Central identifier	PMC7126381
has PubMed identifier	25281775
schema:publication	Fitoterapia
resource representing a document's body	covid:f6d5f516742718fb9229c7bb4abde7bc290c08c5#body_text
is schema:about of	named entity 'IN VITRO' named entity 'metabolism' named entity 'FTA' named entity 'hydroxytyrosol' named entity 'performed' named entity 'BIOLOGICAL' named entity 'PRESENT' named entity 'FECAL' named entity 'HYDROLYSIS' named entity 'ITS' named entity 'USING' named entity 'EFFECTS' named entity 'ANALYSIS' named entity 'DIFFUSION METHOD' named entity 'TO FORM' named entity 'BACTERIA ' named entity 'BACTERIAL' named entity 'INTESTINAL METABOLISM' named entity 'IN VITRO' named entity 'ACID' named entity 'ASSAY' named entity 'METABOLIC PROCESS' named entity 'OBTAINED BY' named entity 'FTA' named entity 'MAY BE' named entity 'DISC' named entity 'FORSYTHOSIDE A' named entity 'DEPENDENT' named entity 'MICROBIAL METABOLISM' named entity 'EVALUATED' named entity 'FORSYTHOSIDE A' named entity 'METABOLITE' named entity 'HEMOLYSIS ' named entity 'CAFFEIC ACID' named entity 'HIGHLY SENSITIVE' named entity 'HYDROXYTYROSOL' named entity 'ANTIMICROBIAL' named entity 'CLARIFY' named entity 'MICROFLORA' named entity 'DCA' named entity 'ACTIVITIES' named entity 'BIOLOGICAL ACTIVITY' named entity 'SOFTWARE' named entity '2C4' named entity 'FECAL' named entity 'METABOLITES' named entity 'HUMAN' named entity 'ACTIVITIES' named entity 'TIME-OF-FLIGHT MASS SPECTROMETRY' named entity 'PERFORMED' named entity 'TOF' named entity 'AGAR' named entity 'INCUBATED' named entity 'CLOT' named entity 'INTESTINAL' named entity 'ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY' named entity 'ANTIENDOTOXIN' named entity 'SPECIFIC' named entity 'LAL' named entity 'METABOLITES' named entity 'MIC VALUE' named entity 'ORALLY' named entity 'ADMINISTERED' named entity 'PHARMACOLOGICAL' named entity 'HIGHER' named entity 'ITS' named entity 'RELATIONSHIP' named entity 'TO INVESTIGATE' named entity 'HUMAN' named entity 'GEL' named entity 'STUDY' covid:arg/f6d5f516742718fb9229c7bb4abde7bc290c08c5 named entity 'hydrogenated' named entity 'antimicrobial' named entity 'liquid chromatography' named entity 'metabolized' named entity 'clot'

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