About: β-Endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM

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About: β-Endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	β-Endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM
Creator	Gilmore, Wendy Moradzadeh, Doris
Source	Elsevier; Medline; PMC
abstract	Abstract The neurotropic murine coronavirus, MHV-JHM (JHMV) causes encephalitis and paralytic-demyelinating disease in susceptible strains of mice and rats, serving as a model for human demyelinating diseases such as multiple sclerosis. In this communication, we report that a single intracerebral administration of the naturally occurring neuropeptide, β-endorphin, reduced the incidence of JHMV-induced paralytic-demyelinating disease 40–50% in C57Bl/6 mice. Protection from disease was accompanied by significantly reduced virus replication in the brain as early as 3 days post-infection and did not occur in irradiated, or immunoincompetent mice. The data suggest that β-endorphin engages immune mechanisms of host resistance to JHMV infection to protect the mice from disease.
has issue date	1993-10-31(xsd:dateTime)
bibo:doi	10.1016/0165-5728(93)90061-3
bibo:pmid	8227310
has license	els-covid
sha1sum (hex)	f633e4c9065ef9226de908514df6ea7d29abe7bf
schema:url	https://doi.org/10.1016/0165-5728%2893%2990061-3
resource representing a document's title	β-Endorphin protects mice from neurological disease induced by the murine coronavirus MHV-JHM
has PubMed Central identifier	PMC7119610
has PubMed identifier	8227310
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:f633e4c9065ef9226de908514df6ea7d29abe7bf#body_text
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