About: Sequestration of RNA by grass carp Ctenopharyngodon idella TIA1 is associated with its positive role in facilitating grass carp reovirus infection

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About: Sequestration of RNA by grass carp Ctenopharyngodon idella TIA1 is associated with its positive role in facilitating grass carp reovirus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sequestration of RNA by grass carp Ctenopharyngodon idella TIA1 is associated with its positive role in facilitating grass carp reovirus infection
Creator	Wang, Hao Lu, Liqun Song, Lang Wang, Tu
Source	Elsevier; Medline; PMC
abstract	Abstract Previous report demonstrated that grass carp reovirus (GCRV) infection resulted in unlinking cellular stress granule formation from aggregation of grass carp Ctenopharyngodon idella TIA1 (CiTIA1). Here, we provided evidence to show that CiTIA1 bound to synthesized ssRNA and dsRNA in vitro. Both GST-pull down assay and RNA immunoprecipitation analysis confirmed the association between GCRV-specific RNA and GST-tagged CiTIA1 in C. idella kidney (CIK) cells. Furthermore, CiTIA1 was shown to protect dsRNA of virus-origin from degradation in CIK cells through Northern blot analysis. Finally, transient overexpression of CiTIA1 enhanced the replication efficiency of GCRV in CIK cells. Taken together, our results suggested that cellular CiTIA1 might facilitate GCRV replication through sequestrating and protecting viral RNA from degradation.
has issue date	2015-10-31(xsd:dateTime)
bibo:doi	10.1016/j.fsi.2015.07.018
bibo:pmid	26208752
has license	els-covid
sha1sum (hex)	f5a577a6b80c1fd6cbc4b7e05412eb78e0a67a79
schema:url	https://doi.org/10.1016/j.fsi.2015.07.018
resource representing a document's title	Sequestration of RNA by grass carp Ctenopharyngodon idella TIA1 is associated with its positive role in facilitating grass carp reovirus infection
has PubMed Central identifier	PMC7173117
has PubMed identifier	26208752
schema:publication	Fish & Shellfish Immunology
resource representing a document's body	covid:f5a577a6b80c1fd6cbc4b7e05412eb78e0a67a79#body_text
is schema:about of	named entity 'formation' named entity 'ssRNA' named entity 'kidney' named entity 'transient' named entity 'assay' named entity 'PABP' named entity 'protein' named entity 'CIK' named entity 'plasmid' named entity 'suggested' named entity 'TIA1' named entity 'dsRNA' named entity 'TIA1' named entity 'virus' named entity 'dsRNA' named entity 'CIK' named entity 'reovirus' named entity 'host cells' named entity 'marker proteins' named entity 'RNAi' named entity 'minus-strand' named entity 'ultrasonication' named entity 'TIAR' named entity 'Western blot' named entity '12,000' named entity 'embryo development' named entity 'reovirus' named entity 'plasmid' named entity 'transfection' named entity 'Shanghai' named entity 'viral replication' named entity 'dsRNA' named entity 'small molecular' named entity 'cytoplasmic' named entity 'TIAR' named entity 'Western blot' named entity 'viral infections' named entity 'cleavage' named entity 'alternative splicing' named entity 'post-transcriptional regulation' named entity 'dsRNA' named entity 'lysis buffer' named entity 'polyclonal antibodies' named entity 'TIAR' named entity 'grass carp' named entity 'interact' named entity 'TIA1' named entity 'RNA' named entity 'dsRNA' named entity 'TIAR' named entity 'TIA1' named entity 'hepatitis C virus' named entity 'CIK' named entity 'dsRNA' named entity '50% tissue culture infective dose' named entity 'Freud' named entity 'nitrocellulose' named entity 'competent cells' named entity 'cellular metabolism' named entity 'RNA' named entity 'adjuvant' named entity 'prokaryotic' named entity 'dsRNA' named entity 'mRNAs' named entity 'infection' named entity 'phosphorylation' named entity 'binding activity' named entity 'steady-state' named entity 'reovirus' named entity 'grass carp' named entity 'Shanghai' named entity 'RNAs' named entity 'TIA-1' named entity 'initiation factor 3' named entity 'inhibit apoptosis' named entity 'pathogenesis' named entity 'over-expressed' named entity 'Invitrogen'

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