About: The role of microbes in the pathogenesis of acute rhinosinusitis in young adults

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About: The role of microbes in the pathogenesis of acute rhinosinusitis in young adults Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The role of microbes in the pathogenesis of acute rhinosinusitis in young adults
Creator	Nikkari, Simo Lappalainen, Maija Tapiainen, Terhi Autio, Timo Koivunen, Petri Koskela, Katja Koskela, Markku Koskenkorva, Timo Alho, Arki€ O, N€ Hemmil€, Heidi Mervi, ; Olli-Pekka, ;
Source	Medline; PMC
abstract	OBJECTIVES/HYPOTHESIS: To provide information on the course of acute rhinosinusitis (ARS) with sequential nasal and paranasal microbiological data and their correlation with clinical outcomes. STUDY DESIGN: We conducted a prospective cohort study among 50 Finnish military recruits with clinically diagnosed ARS in spring 2012. METHODS: We collected symptom, nasal endoscopy, and cone‐beam CT (CBCT) scores during the early (2–3 days from onset) and later phases (9–10 days). We took viral samples from the nasopharynx (multiplex respiratory virus polymerase chain reaction [PCR]), bacterial culture from the middle meatus during both phases, and both viral and bacterial samples from the maxillary sinus aspirate (respiratory virus PCR, bacterial culture, broad‐range bacterial PCR) during the later phase. Cilia destruction and microbial biofilms were sought from a nasal mucosal biopsy sample. RESULTS: We found that 42 (84%) of the subjects had viral nucleic acid in the nasopharynx during ARS. During the early phase, 28 (56%) of the subjects had nontypeable H. influenzae (NTHi) in the middle meatus, which was associated with wider paranasal mucosal changes in CBCT scans and increased symptoms during the study period. After 9 to 10 days from the onset, NTHi was found in the maxillary sinus in eight subjects (40%, 8/20) and led to prolonged symptoms. Bacterial biofilm was ruled out in 39 (78%) cases, and cilia destruction did not correlate with microbiological or clinical outcomes. CONCLUSION: Nasal and paranasal H. influenzae coinfection during viral infection may modify the symptoms and the extent of sinonasal mucosal disease observed in CBCT scans already from the beginning of the ARS episode. LEVEL OF EVIDENCE: N/A. Laryngoscope, 125:E1–E7, 2015
has issue date	2014-08-05(xsd:dateTime)
bibo:doi	10.1002/lary.24862
bibo:pmid	25093843
has license	no-cc
sha1sum (hex)	f536d159ba7db1f0cbeb49f8a5f8536f032be32b
schema:url	https://doi.org/10.1002/lary.24862
resource representing a document's title	The role of microbes in the pathogenesis of acute rhinosinusitis in young adults
has PubMed Central identifier	PMC7165696
has PubMed identifier	25093843
schema:publication	Laryngoscope
resource representing a document's body	covid:f536d159ba7db1f0cbeb49f8a5f8536f032be32b#body_text
is schema:about of	named entity 'ARS' named entity 'Pathogenesis' named entity 'ACUTE RHINOSINUSITIS' named entity 'CORRELATION' named entity 'acute' named entity 'microbiological' named entity 'correlation' named entity 'clinical outcomes' named entity 'Pathogenesis' named entity 'sphenoidal sinuses' named entity 'biopsy' named entity 'middle meatus' named entity 'paracetamol' named entity 'symptom' named entity 'maxillary sinus' named entity 'H. influenzae' named entity 'H. influenzae' named entity 'pathogens' named entity 'pneumonia' named entity 'clinical outcomes' named entity 'symptom' named entity 'topical anesthesia' named entity 'middle meatus' named entity 'epithelial' named entity 'NTHi' named entity 'bacteria' named entity 'NTHi' named entity 'Tuusula' named entity 'otolaryngologists' named entity 'NTHi' named entity 'clinical outcomes' named entity 'endoscopy' named entity 'symptom' named entity 'paranasal sinuses' named entity 'middle meatus' named entity 'nasopharyngeal' named entity 'symptom' named entity 'nasopharyngeal' named entity 'Scanning Electron Microscopy' named entity 'nasal discharge' named entity 'aerobic' named entity 'bacterial pathogens' named entity 'Paranasal Sinuses' named entity 'pathogenesis' named entity 'middle meatus' named entity 'nucleic acid' named entity 'gene' named entity 'acute respiratory infection' named entity 'bacterial culture' named entity 'Hilden' named entity 'Polymerase Chain Reaction' named entity 'ciliary epithelium' named entity 'symptom' named entity 'nucleic acid' named entity 'endoscopy' named entity 'puncture needle' named entity 'NTHi' named entity 'influenza A and B viruses' named entity 'Middle Meatus' named entity 'standard deviation' named entity 'maxillary sinus' named entity 'viruses' named entity 'influenza' named entity 'viral infection' named entity 'dizziness' named entity 'aspirates' named entity 'Qiagen' named entity 'mucosal disease' named entity 'clinical outcomes'

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