About: Helicobacter Hypothesis for Idiopathic Parkinsonism: Before and Beyond

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Helicobacter Hypothesis for Idiopathic Parkinsonism: Before and Beyond
Creator	Curry, Alan Ellis, David Charlett, André Williams, John Sudhanva, Malur Owen, Robert Dobbs, Sylvia Ibrahim, Mohammad Oxlade, Norman Price, Ashley Sanderson, Jeremy Weller, Clive Bjarnason, T Dobbs, Dobbs, R Ingvar, ¶ John, Drs Mccrossan, Maria O'donohue, John
Source	Medline; PMC
abstract	We challenge the concept of idiopathic parkinsonism (IP) as inevitably progressive neurodegeneration, proposing a natural history of sequential microbial insults with predisposing host response. Proof‐of‐principle that infection can contribute to IP was provided by case studies and a placebo‐controlled efficacy study of Helicobacter eradication. “Malignant” IP appears converted to “benign”, but marked deterioration accompanies failure. Similar benefit on brady/hypokinesia from eradicating “low‐density” infection favors autoimmunity. Although a minority of UK probands are urea breath test positive for Helicobacter, the predicted probability of having the parkinsonian label depends on the serum H. pylori antibody profile, with clinically relevant gradients between this “discriminant index” and disease burden and progression. In IP, H. pylori antibodies discriminate for persistently abnormal bowel function, and specific abnormal duodenal enterocyte mitochondrial morphology is described in relation to H. pylori infection. Slow intestinal transit manifests as constipation from the prodrome. Diarrhea may flag secondary small‐intestinal bacterial overgrowth. This, coupled with genetically determined intense inflammatory response, might explain evolution from brady/hypokinetic to rigidity‐predominant parkinsonism.
has issue date	2008-08-13(xsd:dateTime)
bibo:doi	10.1111/j.1523-5378.2008.00622.x
bibo:pmid	19250506
has license	no-cc
sha1sum (hex)	f431071a01741876efc148cd3a148de4398e7592
schema:url	https://doi.org/10.1111/j.1523-5378.2008.00622.x
resource representing a document's title	Helicobacter Hypothesis for Idiopathic Parkinsonism: Before and Beyond
has PubMed Central identifier	PMC7165675
has PubMed identifier	19250506
schema:publication	Helicobacter
resource representing a document's body	covid:f431071a01741876efc148cd3a148de4398e7592#body_text
is schema:about of	named entity 'intestinal' named entity 'minority' named entity 'CHALLENGE' named entity 'AUTOIMMUNITY' named entity 'ERADICATION' named entity 'PROGRESSIVE NEURODEGENERATION' named entity 'SERUM' named entity 'NATURAL HISTORY' named entity 'INFLAMMATORY RESPONSE' named entity 'DISEASE' named entity 'INTENSE' named entity 'SMALL' named entity 'PRINCIPLE' named entity 'BOWEL FUNCTION' named entity 'discriminate' named entity 'host response' named entity 'profile' named entity 'autoimmunity' named entity 'H. pylori' named entity 'eradication' named entity 'constipation' named entity 'parkinsonism' named entity 'disease burden' named entity 'H. pylori' named entity 'microbial' named entity 'relation' named entity 'progression' named entity 'morphology' named entity 'hypokinetic' named entity 'prodrome' named entity 'intestinal bacterial overgrowth' named entity 'Malignant' named entity 'neurodegeneration' named entity 'inflammatory response' named entity 'hypokinesia' named entity 'chromatin' named entity 'Mitochondrial' named entity 'H. pylori' named entity 'inflammatory responses' named entity 'central nervous' named entity 'antimuscarinics' named entity 'H. pylori' named entity 'infection' named entity 'lymphopenia' named entity 'Helicobacter' named entity 'immunodeficiency' named entity 'HIV' named entity 'Levodopa' named entity 'nigrostriatal' named entity 'H. pylori' named entity 'immunoblot' named entity 'immunodeficiency' named entity 'birth cohort' named entity 'placebo' named entity 'reduces inflammation' named entity 'CagA' named entity 'Helicobacter' named entity 'defecation' named entity 'parkinsonism' named entity 'encephalitis lethargica' named entity 'neurones' named entity 'antigens' named entity 'probands'

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