About: Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs

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About: Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs
Creator	Summerfield, Artur Ruggli, Nicolas Zimmer, Gert Eck, Melanie Locher, Samira Sarraseca, Javier Durán, Margarita Mccullough, Kenneth Ricklin, Meret Rodríguez, María
Source	Medline; PMC
abstract	Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of one of the most devastating and economically significant viral disease of pigs worldwide. The vaccines currently available on the market elicit only limited protection. Recombinant vesicular stomatitis virus (VSV) replicon particles (VRP) have been used successfully to induce protection against influenza A virus (IAV) in chickens and bluetongue virus in sheep. In this study, VSV VRP expressing the PRRSV envelope proteins GP5, M, GP4, GP3, GP2 and the nucleocapsid protein N, individually or in combination, were generated and evaluated as a potential vector vaccine against PRRSV infection. High level expression of the recombinant PRRSV proteins was demonstrated in cell culture. However, none of the PRRSV antigens expressed from VRP, with the exception of the N protein, did induce any detectable antibody response in pigs before challenge infection with PRRSV. After challenge however, the antibody responses against GP5, GP4 and GP3 appeared in average 2 weeks earlier than in pigs vaccinated with the empty control VRP. No reduction of viremia was observed in the vaccinated group compared with the control group. When pigs were co-vaccinated with VRP expressing IAV antigens and VRP expressing PRRSV glycoproteins, only antibody responses to the IAV antigens were detectable. These data show that the VSV replicon vector can induce immune responses to heterologous proteins in pigs, but that the PRRSV envelope proteins expressed from VSV VRP are poorly immunogenic. Nevertheless, they prime the immune system for significantly earlier B-cell responses following PRRSV challenge infection.
has issue date	2016-02-19(xsd:dateTime)
bibo:doi	10.1186/s13567-016-0318-0
bibo:pmid	26895704
has license	cc-by
sha1sum (hex)	f3869eb49905ee75dbd6acd2964cb74f69154b2a
schema:url	https://doi.org/10.1186/s13567-016-0318-0
resource representing a document's title	Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs
has PubMed Central identifier	PMC4761149
has PubMed identifier	26895704
schema:publication	Vet Res
resource representing a document's body	covid:f3869eb49905ee75dbd6acd2964cb74f69154b2a#body_text
is schema:about of	named entity 'PIGS' named entity 'GP3' named entity 'responses' named entity 'High' named entity 'nucleocapsid' named entity 'pigs' named entity 'expressing' named entity 'responses' named entity 'porcine' named entity 'VIREMIA' named entity 'DO NOT' named entity 'PIGS' named entity 'CONTROL GROUP' named entity 'AVERAGE' named entity 'PARTICLES' named entity 'RESPONSES' named entity 'GP4' named entity 'PROTECTION' named entity 'REPLICON' named entity 'INDUCE' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'EXPRESSION' named entity 'LIMITED' named entity 'DEMONSTRATED' named entity 'POORLY' named entity 'NUCLEOCAPSID PROTEIN' named entity 'DETECTABLE' named entity 'ANTIGENS' named entity 'RECOMBINANT' named entity 'CAUSATIVE AGENT' named entity 'SHEEP' named entity 'ECONOMICALLY' named entity 'VECTOR VACCINE' named entity 'GP2' named entity 'VRP' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'AVAILABLE' named entity 'GP5' named entity 'COMBINATION' named entity 'WORLDWIDE' named entity 'CHICKENS' named entity 'INFECTION' named entity 'INFLUENZA A VIRUS' named entity 'EXCEPTION' named entity 'GLYCOPROTEINS' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'VIRUS' named entity 'VACCINATED' named entity 'COMPARED' named entity 'GENERATED' named entity 'PROTEINS' named entity 'VIRAL DISEASE' named entity 'USED' named entity 'EVALUATED' named entity 'ANTIBODY' named entity 'IMMUNE RESPONSES' named entity 'VACCINES' named entity 'IMMUNE SYSTEM' named entity 'PROTEINS' named entity 'PRIMING' named entity 'PROTECTION' named entity 'EXPRESSED' named entity 'PRIME' named entity 'IMMUNE' named entity 'HIGH LEVEL' named entity 'ONE OF' named entity 'STUDY' named entity 'CONTROL' named entity 'B-CELL' named entity 'ENVELOPE' named entity 'OBSERVED' named entity '2 WEEKS'

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