About: Mechanisms of viral entry: sneaking in the front door

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About: Mechanisms of viral entry: sneaking in the front door Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanisms of viral entry: sneaking in the front door
Creator	Mckeating, Jane Rappoport, Joshua Thorley, Jennifer
topic	covid:f2cc8e8c4fa06d2af961fe2c2bab8c2d1e2849b3#this
Source	Medline; PMC
abstract	Recent developments in methods to study virus internalisation are providing clearer insights into mechanisms used by viruses to enter host cells. The use of dominant negative constructs, specific inhibitory drugs and RNAi to selectively prevent entry through particular pathways has provided evidence for the clathrin-mediated entry of hepatitis C virus (HCV) as well as the caveolar entry of Simian Virus 40. Moreover, the ability to image and track fluorescent-labelled virus particles in real-time has begun to challenge the classical plasma membrane entry mechanisms described for poliovirus and human immunodeficiency virus. This review will cover both well-documented entry mechanisms as well as more recent discoveries in the entry pathways of enveloped and non-enveloped viruses. This will include viruses which enter the cytosol directly at the plasma membrane and those which enter via endocytosis and traversal of internal membrane barrier(s). Recent developments in imaging and inhibition of entry pathways have provided insights into the ill-defined entry mechanism of HCV, bringing it to the forefront of viral entry research. Finally, as high-affinity receptors often define viral internalisation pathways, and tropism in vivo, host membrane proteins to which viral particles specifically bind will be discussed throughout.
has issue date	2010-05-06(xsd:dateTime)
bibo:doi	10.1007/s00709-010-0152-6
bibo:pmid	20446005
has license	no-cc
sha1sum (hex)	f2cc8e8c4fa06d2af961fe2c2bab8c2d1e2849b3
schema:url	https://doi.org/10.1007/s00709-010-0152-6
resource representing a document's title	Mechanisms of viral entry: sneaking in the front door
has PubMed Central identifier	PMC3038234
has PubMed identifier	20446005
schema:publication	Protoplasma
resource representing a document's body	covid:f2cc8e8c4fa06d2af961fe2c2bab8c2d1e2849b3#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/f2cc8e8c4fa06d2af961fe2c2bab8c2d1e2849b3
is schema:about of	named entity 'FRONT DOOR' named entity 'enter' named entity 'internal' named entity 'membrane' named entity 'membrane proteins' named entity 'dominant' named entity 'developments' named entity 'internalisation' named entity 'Mechanisms' named entity 'MEMBRANE PROTEINS' named entity 'PATHWAYS' named entity 'MECHANISM' named entity 'TRAVERSAL' named entity 'PLASMA MEMBRANE' named entity 'HIGH' named entity 'PREVENT' named entity 'RECENT' named entity 'VIRAL ENTRY' named entity 'COVER' named entity 'DOCUMENTED' named entity 'ENTRY' named entity 'IMAGE' named entity 'CHALLENGE' named entity 'BARRIER' named entity 'MEDIATED' named entity 'MECHANISMS' named entity 'VIRAL ENTRY' named entity 'TRACK' named entity 'SIMIAN VIRUS 40' named entity 'DRUGS' named entity '28S' named entity 'PROVIDED' named entity 'INHIBITION' named entity 'STUDY' named entity 'DEVELOPMENTS' named entity 'IMAGING' named entity 'PROVIDING' named entity 'HCV' named entity 'DIRECTLY' named entity 'FLUORESCENT' named entity 'INHIBITORY' named entity 'RESEARCH' named entity 'DESCRIBED' named entity 'METHODS' named entity 'AFFINITY' named entity 'HEPATITIS C VIRUS' named entity 'ENTER' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'REVIEW' named entity 'INCLUDE' named entity 'CLATHRIN' named entity 'MEMBRANE' named entity 'CLASSICAL' named entity 'INSIGHTS' named entity 'PARTICULAR' named entity 'BIND' named entity 'VIRAL PARTICLES' named entity 'ENDOCYTOSIS' named entity 'CYTOSOL' named entity 'USE OF' named entity 'NON-' named entity 'RNAI' named entity 'TROPISM' named entity 'VIRAL' named entity 'VIRUS PARTICLES' named entity 'POLIOVIRUS' named entity 'RECEPTORS' named entity 'IN VIVO' named entity 'ILL-DEFINED' named entity 'EVIDENCE FOR' named entity 'SPECIFIC' named entity 'HOST' named entity 'HOST CELLS' named entity 'VIRUS' named entity 'DOMINANT NEGATIVE' named entity 'HAVE' named entity 'USED BY'

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