About: Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection

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About: Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection
Creator	Jing-Zhen, Tian Li, Ya-Qun Qing-Hua, Cui Rui-Kun, D Zi-Kai, Geng
Source	Elsevier; Medline; PMC
abstract	Abstract Ge Gen Decoction (GGD), a Traditional Chinese Medicine prescription, is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus (IAV) infection. However, the underlying mechanism of GGD against IAV infection remains unclear. In this study, we found that GGD had moderate anti-IAV activity in vitro. GGD was more effective when given before the viral infection and targeted the viral attachment and replication stages rather than the internalization stage. In vivo, GGD treatment reduced thevirus titers of lung tissue significantly and improved the survival rate, lung index, and pulmonary histopathological changes in H1N1-infected mice. We observed the changes in several key immuno-related indexes in GGD administrated H1N1-infected mice with anti-IAV drug oseltamivir phosphate as the control. GGD treatment decreased the expression of TNF-α and improved Th1/Th2 immune balance to reduce the excessive immune response in H1N1-infected mice. Besides, the expression of the toll-like receptor 7 signaling pathway in H1N1-infected mice decreased after GGD treatment. Our results showed that GGD has anti-IAV activity and can modulate the immune system to relieve lung inflammation.
has issue date	2019-09-30(xsd:dateTime)
bibo:doi	10.1016/s1875-5364(19)30079-2
bibo:pmid	31526500
has license	els-covid
sha1sum (hex)	efc40fc57c0832923577b3f3fea326be41143765
schema:url	https://doi.org/10.1016/s1875-5364%2819%2930079-2
resource representing a document's title	Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection
has PubMed Central identifier	PMC7128581
has PubMed identifier	31526500
schema:publication	Chinese Journal of Natural Medicines
resource representing a document's body	covid:efc40fc57c0832923577b3f3fea326be41143765#body_text
is schema:about of	named entity 'observed' named entity 'lung' named entity 'relieve' named entity 'H1N1' named entity 'internalization' named entity 'viral' named entity 'mice' named entity 'RESULTS' named entity 'INFECTED' named entity 'MODULATE' named entity 'TOLL-LIKE RECEPTOR 7 SIGNALING PATHWAY' named entity 'VIRAL ATTACHMENT' named entity 'INFLUENZA A VIRUS' named entity 'FOUND' named entity 'RESPIRATORY DISEASES' named entity 'INFECTION' named entity 'LUNG TISSUE' named entity 'RELIEVE' named entity 'KEY' named entity 'TARGETED' named entity 'SYMPTOMS' named entity 'DRUG' named entity 'LUNG INFLAMMATION' named entity 'IMMUNE' named entity 'TH1' named entity 'MICE' named entity 'USED' named entity 'MECHANISM' named entity 'STUDY' named entity 'DECOCTION' named entity 'UNCLEAR' named entity 'INDEX' named entity 'BALANCE' named entity 'IMMUNE SYSTEM' named entity 'CONTROL' named entity 'OUR' named entity 'IN VIVO' named entity 'TRADITIONAL CHINESE MEDICINE' named entity 'SURVIVAL RATE' named entity 'DECOCTION' named entity 'TREAT' named entity 'LUNG' named entity 'GE GEN' named entity 'VIRAL INFECTION' named entity 'EXPLORATION' named entity 'TREATMENT' named entity 'UNDERLYING' named entity 'MECHANISMS' named entity 'INFLUENZA A VIRUS INFECTION' named entity 'MEDICINES' named entity 'IN VITRO' named entity 'INDEXES' named entity 'RELATED' named entity 'CHANGES' named entity 'PRESCRIPTION' named entity 'ACTIVITY' named entity 'CHINESE' named entity 'NATURAL' named entity 'JOURNAL ' named entity 'RATHER' named entity 'EXCESSIVE' named entity 'INFECTIOUS' named entity 'OBSERVED' named entity 'STAGES' named entity 'MODERATE' named entity 'OSELTAMIVIR PHOSPHATE' named entity 'REPLICATION' named entity 'DECREASED' named entity 'VIRUS' named entity 'GIVEN' named entity 'REDUCED' named entity 'H1N1' named entity 'GE GEN' named entity 'TO REDUCE' named entity 'INTERNALIZATION' named entity 'PULMONARY' named entity 'EFFECTIVE'

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