About: Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

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About: Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross
Creator	Baric, Ralph Frieman, Matthew Gralinski, Lisa Valdar, William Whitmore, Alan Heise, Mark Threadgill, David Deming, Damon Green, Richard Menachery, Vineet Ferris, Martin Aylor, David Bell, Timothy Buus, Ryan Churchill, Gary Katze, Michael Mcmillan, Leonard Miller, Darla Pardo-Manuel De Villena, Fernando
source	Medline; PMC
abstract	New systems genetics approaches are needed to rapidly identify host genes and genetic networks that regulate complex disease outcomes. Using genetically diverse animals from incipient lines of the Collaborative Cross mouse panel, we demonstrate a greatly expanded range of phenotypes relative to classical mouse models of SARS-CoV infection including lung pathology, weight loss and viral titer. Genetic mapping revealed several loci contributing to differential disease responses, including an 8.5Mb locus associated with vascular cuffing on chromosome 3 that contained 23 genes and 13 noncoding RNAs. Integrating phenotypic and genetic data narrowed this region to a single gene, Trim55, an E3 ubiquitin ligase with a role in muscle fiber maintenance. Lung pathology and transcriptomic data from mice genetically deficient in Trim55 were used to validate its role in SARS-CoV-induced vascular cuffing and inflammation. These data establish the Collaborative Cross platform as a powerful genetic resource for uncovering genetic contributions of complex traits in microbial disease severity, inflammation and virus replication in models of outbred populations.
has issue date	2015-10-09(xsd:dateTime)
bibo:doi	10.1371/journal.pgen.1005504
bibo:pmid	26452100
has license	cc0
sha1sum (hex)	edea2cda674c33bb251b64e5416f5380f13d5489
schema:url	https://doi.org/10.1371/journal.pgen.1005504
resource representing a document's title	Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross
has PubMed Central identifier	PMC4599853
has PubMed identifier	26452100
schema:publication	PLoS Genet
resource representing a document's body	covid:edea2cda674c33bb251b64e5416f5380f13d5489#body_text
is schema:about of	named entity 'transcriptomic' named entity 'demonstrate' named entity 'region' named entity 'viral' named entity 'PHENOTYPIC' named entity 'CROSS' named entity 'INTEGRATING' named entity 'COLLABORATIVE' named entity 'SARS-COV INFECTION' named entity 'LINES' named entity 'MOUSE MODELS' named entity 'GENETIC RESOURCE' named entity 'ITS' named entity 'OUTCOMES' named entity 'MODELS' named entity 'SARS-COV' named entity 'REGION' named entity 'DIVERSE' named entity 'VIRUS REPLICATION' named entity 'E3 UBIQUITIN LIGASE' named entity 'CLASSICAL' named entity 'GENETIC MAPPING' named entity 'GENETIC NETWORKS' named entity 'COMPLEX TRAITS' named entity 'RESPONSES' named entity 'PANEL' named entity 'NARROWED' named entity 'COMPLEX DISEASE' named entity 'APPROACHES' named entity 'DISEASE SEVERITY' named entity 'GENETIC' named entity 'SYSTEMS' named entity 'MUSCLE FIBER MAINTENANCE' named entity 'IDENTIFY' named entity 'VASCULAR CUFFING' named entity 'REVEALED' named entity 'RAPIDLY' named entity 'GREATLY' named entity 'MICE' named entity 'ANIMALS' named entity 'LUNG' named entity 'NEEDED' named entity 'PATHOLOGY' named entity 'OUTBRED' named entity 'MOUSE' named entity 'CONTAINED' named entity 'SINGLE' named entity 'REGULATE' named entity 'INCLUDING' named entity 'UNCOVERING' named entity 'NEW' named entity 'PHENOTYPES' named entity 'POPULATIONS' named entity 'USED' named entity 'LOCUS' named entity 'DEFICIENT' named entity 'ESTABLISH' named entity 'WEIGHT LOSS' named entity 'USING' covid:arg/edea2cda674c33bb251b64e5416f5380f13d5489 named entity 'CONTRIBUTING' named entity 'USING' named entity 'COLLABORATIVE'

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