About: A large-scale binding and functional map of human RNA-binding proteins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A large-scale binding and functional map of human RNA-binding proteins
Creator	Duff, Michael Xiao, Rui Wang, Xiaofeng Zhou, Bing Aigner, Stefan Bazile, Cassandra Bergalet, Julie Blue, Steven Bouvrette, Benoit Burge, Christopher Chen, Jia-Yu Cody, Neal Dominguez, Daniel Freese, Peter Fu, Xiang-Dong Garcia, Keri Gelboin-Burkhart, Chelsea Graveley, Brenton Hochman, Myles Lambert, Nicole Li, Hairi Louie, Ashley Lécuyer, Eric Mcgurk, Michael Nguyen, Thai Olson, Sara Palden, Tsultrim Philip, Louis Pratt, Gabriel Rabano, Ines Sathe, Shashank Stanton, Rebecca Su, Amanda Sundararaman, Balaji Van Nostrand, Eric Wang, Ruth Wei, Xintao Yee, Brian Yeo, Gene Zhan, Lijun
Source	PMC
abstract	Many proteins regulate the expression of genes by binding to specific regions encoded in the genome(1). Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part of the Encyclopedia of DNA Elements (ENCODE) project phase III. This class of regulatory elements functions only when transcribed into RNA, as they serve as the binding sites for RBPs that control post-transcriptional processes such as splicing, cleavage and polyadenylation, and the editing, localization, stability and translation of mRNAs. We describe the mapping and characterization of RNA elements recognized by a large collection of human RBPs in K562 and HepG2 cells. Integrative analyses using five assays identify RBP binding sites on RNA and chromatin in vivo, the in vitro binding preferences of RBPs, the function of RBP binding sites and the subcellular localization of RBPs, producing 1,223 replicated data sets for 356 RBPs. We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs.
has issue date	2020-07-29(xsd:dateTime)
bibo:doi	10.1038/s41586-020-2077-3
bibo:pmid	32728246
has license	cc-by
sha1sum (hex)	ede5dc4eb66b68b10cbd640b0a36318eed50599b
schema:url	https://doi.org/10.1038/s41586-020-2077-3
resource representing a document's title	A large-scale binding and functional map of human RNA-binding proteins
has PubMed Central identifier	PMC7410833
has PubMed identifier	32728246
schema:publication	Nature
resource representing a document's body	covid:ede5dc4eb66b68b10cbd640b0a36318eed50599b#body_text
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