About: Targeting deubiquitinase USP28 for cancer therapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Targeting deubiquitinase USP28 for cancer therapy
Creator	Zhang, Li Jia, Lijun Yu, Xiaoli Zhang, Zhen Feng, Yan Chen, Xingxing Fu, Shen Guo, Xiaomao Liu, Zhiyi Luo, Jurui Ma, Jinli Mei, Xin Shao, Zhimin Wang, Xiaofang Wei, Dongping Yang, Zhaozhi Zhou, Zhirui
source	Medline; PMC
abstract	As one of the most important post-translational modifications, ubiquitination plays versatile roles in cancer-related pathways, and is involved in protein metabolism, cell-cycle progression, apoptosis, and transcription. Counteracting the activities of the E3 ligases, the deubiquitylating enzymes have been suggested as another important mechanism to modulate the ubiquitination process, and are implicated in cancer as well. In this article, we review the emerging roles of USP28 in cancer pathways as revealed by recent studies. We discuss the major mechanisms by which USP28 is involved in the cancer-related pathways, whereby USP28 regulates physiological homeostasis of ubiquitination process, DNA-damage response, and cell cycle during genotoxic stress. We further review the studies where USP28 was targeted for treating multiples cancers including non-small cell lung cancer, breast cancer, intestinal cancers, gliomas, and bladder cancer. As a result, the clinical significance of targeting USP28 for cancer therapy merits further exploration and demonstration.
has issue date	2018-02-07(xsd:dateTime)
bibo:doi	10.1038/s41419-017-0208-z
bibo:pmid	29415985
has license	cc-by
sha1sum (hex)	ecf2675fbb7883ca4a8f98c34eadb55c6b857aaa
schema:url	https://doi.org/10.1038/s41419-017-0208-z
resource representing a document's title	Targeting deubiquitinase USP28 for cancer therapy
has PubMed Central identifier	PMC5833459
has PubMed identifier	29415985
schema:publication	Cell Death Dis
resource representing a document's body	covid:ecf2675fbb7883ca4a8f98c34eadb55c6b857aaa#body_text
is schema:about of	named entity 'TARGETING' named entity 'cell cycle' named entity 'enzymes' named entity 'cancer therapy' named entity 'RECENT' named entity 'WHERE' named entity 'DAMAGE RESPONSE' named entity 'MULTIPLES' named entity 'INTESTINAL CANCERS' named entity 'IMPORTANT' named entity 'INCLUDING' named entity 'TREATING' named entity 'PLAYS' named entity 'MAJOR' named entity 'NON-SMALL CELL LUNG CANCER' named entity 'REVEALED' named entity 'ACTIVITIES' named entity 'LIGASES' named entity 'APOPTOSIS' named entity 'PROGRESSION' named entity 'MODULATE' named entity 'RESULT' named entity 'UBIQUITINATION' named entity 'DNA-DAMAGE' named entity 'INVOLVED' named entity 'REVIEW' named entity 'CLINICAL SIGNIFICANCE' named entity 'GLIOMAS' named entity 'MECHANISM' named entity 'TRANSCRIPTION' named entity 'CANCER' named entity 'TARGETING' named entity 'ONE OF' named entity 'PROTEIN METABOLISM' named entity 'STUDIES' named entity 'MECHANISMS' named entity 'GENOTOXIC STRESS' named entity 'DEMONSTRATION' named entity 'EXPLORATION' named entity 'DEUBIQUITINASE' named entity 'CANCER THERAPY' named entity 'BREAST CANCER' named entity 'PATHWAYS' named entity 'RELATED' named entity 'PHYSIOLOGICAL HOMEOSTASIS' named entity 'ARTICLE' named entity 'BLADDER CANCER' named entity 'PROCESS' named entity 'CELL CYCLE' named entity 'ENZYMES' named entity 'CELL-CYCLE' named entity 'USP28' named entity 'ROLES' named entity 'USP28' named entity 'POST-TRANSLATIONAL MODIFICATIONS' named entity 'DISCUSS' named entity 'HAVE' named entity 'CANCERS' named entity 'CANCER THERAPY' named entity 'TARGETED' named entity '2C CELL' covid:arg/ecf2675fbb7883ca4a8f98c34eadb55c6b857aaa named entity 'process' named entity 'apoptosis' named entity 'transcription'

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