About: The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine
Creator	Zúñiga, Joaquín Khader, Shabaana Choreño-Parra, José Thirunavukkarasu, Shyamala Edu, Sakhader@wustl
Source	Elsevier; Medline; PMC
abstract	Abstract C-X-C motif chemokine 17 (CXCL-17) is a novel chemokine that plays a functional role maintaining homeostasis at distinct mucosal barriers, including regulation of myeloid-cell recruitment, angiogenesis, and control of microorganisms. Particularly, CXCL17 is produced along the epithelium of the airways both at steady state and under inflammatory conditions. While increased CXCL17 expression is associated with disease progression in pulmonary fibrosis, asthma, and lung/hepatic cancer, it is thought to play a protective role in pancreatic cancer, autoimmune encephalomyelitis and viral infections. Thus, there is emerging evidence pointing to both a harmful and protective role for CXCL17 in human health and disease, with therapeutic potential for translational applications. In this review, we provide an overview of the discovery, characteristics and functions of CXCL17 emphasizing its clinical potential in respiratory disorders.
has issue date	2020-04-23(xsd:dateTime)
bibo:doi	10.1016/j.cytogfr.2020.04.004
bibo:pmid	32345516
has license	els-covid
sha1sum (hex)	ece496d8cff30da5919f1416be9c29576b3c5476
schema:url	https://doi.org/10.1016/j.cytogfr.2020.04.004
resource representing a document's title	The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine
has PubMed Central identifier	PMC7177079
has PubMed identifier	32345516
schema:publication	Cytokine Growth Factor Rev
resource representing a document's body	covid:ece496d8cff30da5919f1416be9c29576b3c5476#body_text
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