About: TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling

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About: TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling
Creator	Huang, Yong Ding, Li Tong, Dewen Xu, Xingang Du, Qian Zhao, Xiaomin Zhang, Wenlong Dong, Feng
Source	Elsevier; Medline; PMC
abstract	Abstract Our previous studies showed that TGEV infection could induce cell cycle arrest and apoptosis via activation of p53 signaling in cultured host cells. However, it is unclear which viral gene causes these effects. In this study, we investigated the effects of TGEV nucleocapsid (N) protein on PK-15 cells. We found that TGEV N protein suppressed cell proliferation by causing cell cycle arrest at the S and G2/M phases and apoptosis. Characterization of various cellular proteins that are involved in regulating cell cycle progression demonstrated that the expression of N gene resulted in an accumulation of p53 and p21, which suppressed cyclin B1, cdc2 and cdk2 expression. Moreover, the expression of TGEV N gene promoted translocation of Bax to mitochondria, which in turn caused the release of cytochrome c, followed by activation of caspase-3, resulting in cell apoptosis in the transfected PK-15 cells following cell cycle arrest. Further studies showed that p53 inhibitor attenuated TGEV N protein induced cell cycle arrest at S and G2/M phases and apoptosis through reversing the expression changes of cdc2, cdk2 and cyclin B1 and the translocation changes of Bax and cytochrome c induced by TGEV N protein. Taken together, these results demonstrated that TGEV N protein might play an important role in TGEV infection-induced p53 activation and cell cycle arrest at the S and G2/M phases and apoptosis occurrence.
has issue date	2014-03-07(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2014.02.039
bibo:pmid	24548406
has license	els-covid
sha1sum (hex)	ecb9a19c4b8cb6167cdddffa5db9aa210e9165ab
schema:url	https://doi.org/10.1016/j.bbrc.2014.02.039
resource representing a document's title	TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling
has PubMed Central identifier	PMC7092941
has PubMed identifier	24548406
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:ecb9a19c4b8cb6167cdddffa5db9aa210e9165ab#body_text
is schema:about of	named entity 'induced' named entity 'phases' named entity 'demonstrated' named entity 'cells' named entity 'caused' named entity 'effects' named entity 'apoptosis' named entity 'accumulation' named entity 'apoptosis' named entity 'reversing' named entity 'caspase' named entity 'PLAY' named entity 'SIGNALING' named entity 'P21' named entity 'CAUSING' named entity 'INDUCED' named entity 'ACTIVATION' named entity 'NUCLEOCAPSID' named entity 'CELLS' named entity 'VARIOUS' named entity 'P53 INHIBITOR' named entity 'ACTIVATION OF CASPASE-3' named entity 'N PROTEIN' named entity 'STUDY' named entity 'PROTEIN ' named entity 'TRANSLOCATION' named entity 'ROLE' named entity 'CELL' named entity 'FOLLOWED BY' named entity 'CHARACTERIZATION' named entity 'RESULTING IN' named entity 'CDK2' named entity 'CELLULAR' named entity 'EXPRESSION' named entity 'STUDIES' named entity 'INFECTION' named entity 'INVOLVED' named entity 'TAKEN' named entity 'INVESTIGATED' named entity 'UNCLEAR' named entity 'IMPORTANT' named entity 'VIRAL GENE' named entity 'P53 ACTIVATION' named entity 'PREVIOUS' named entity 'DEMONSTRATED' named entity 'CDC2' named entity 'BAX' named entity 'PHASES' named entity 'RELEASE' named entity 'RESULTS' named entity 'CELL PROLIFERATION' named entity 'APOPTOSIS' named entity 'OCCURRENCE' named entity 'HOST CELLS' named entity 'P53' named entity 'TGEV' named entity 'OUR' named entity 'CAUSES' named entity 'EFFECTS' named entity 'CELL CYCLE ARREST' named entity 'THESE' named entity 'CYCLIN B1' named entity 'CELL CYCLE PROGRESSION' named entity 'CYTOCHROME C' named entity 'INDUCE' named entity 'CULTURED' named entity 'TURN' named entity 'SUPPRESSED' named entity 'MITOCHONDRIA' named entity 'ACCUMULATION' named entity 'FOUND' named entity 'TRANSLOCATION OF BAX' named entity 'FOLLOWING' named entity 'REGULATING'

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